{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:07:10Z","timestamp":1792260430774,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We examined the progression of extrapyramidal symptoms and signs in autopsy\u2010confirmed dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD), and Alzheimer's disease dementia (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Longitudinal data were obtained from Arizona Study of Aging and Neurodegenerative Disease, with PDD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a098), AD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a047) and DLB (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a048) further sub\u2010grouped as with or without parkinsonism (DLB+ and DLB\u2212). Within\u2010group Unified Parkinson's Disease Rating Scale (UPDRS) \u2010II and UPDRS\u2010III trajectories were analyzed using non\u2010linear mixed effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In DLB, 65.6% had parkinsonism. Baseline UPDRS\u2010II and III scores (off\u2010stage) were highest (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) for PDD (mean\u00a0\u00b1\u00a0SD 14.3\u00a0\u00b1\u00a07.8 and 27.4\u00a0\u00b1\u00a016.3), followed by DLB+ (6.0\u00a0\u00b1\u00a08.8 and 17.2\u00a0\u00b1\u00a017.1), DLB\u2212 (1.1\u00a0\u00b1\u00a01.3 and 3.3\u00a0\u00b1\u00a05.5) and AD (3.2\u00a0\u00b1\u00a06.1 and 8.2\u00a0\u00b1\u00a013.6). Compared to PDD, the DLB+ group had faster UPDRS\u2010III progression over 8\u2010years (Cohen's\u2010\n                      <jats:italic>d<\/jats:italic>\n                      range 0.98 to 2.79,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), driven by gait (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and limb bradykinesia (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02) subscales.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Motor deficits progress faster in DLB+ than PDD, providing insights about expected changes in motor function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Dementia with Lewy bodies has faster motor progression than Parkinson's disease dementia<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Linear and non\u2010linear mixed modeling analysis of longitudinal data was utilized<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings have implications for clinical prognostication and trial design<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13357","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T20:39:55Z","timestamp":1688848795000},"page":"4377-4387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Longitudinal motor decline in dementia with Lewy bodies, Parkinson disease dementia, and Alzheimer's dementia in a community autopsy cohort"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8750-1160","authenticated-orcid":false,"given":"Parichita","family":"Choudhury","sequence":"first","affiliation":[{"name":"Cleo Roberts Center Banner Sun Health Research Institute Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic College of Medicine Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[{"name":"Computational Imaging Lab Banner Alzheimer's Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Belden","sequence":"additional","affiliation":[{"name":"Cleo Roberts Center Banner Sun Health Research Institute Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Driver\u2010Dunckley","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamal H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Shprecher","sequence":"additional","affiliation":[{"name":"Cleo Roberts Center Banner Sun Health Research Institute Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geidy E.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Civin Laboratory for Neuropathology Banner Sun Health Research Institute Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A.","family":"Shill","sequence":"additional","affiliation":[{"name":"Department of Neurology Barrow Neurological Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Beach","sequence":"additional","affiliation":[{"name":"Civin Laboratory for Neuropathology 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