{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:04:29Z","timestamp":1788411869654,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>This study aims to examine whether physical activity moderates the association between biomarkers of brain pathologies and dementia risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>From the Memento cohort, we analyzed 1044 patients with mild cognitive impairment, aged 60 and older. Self\u2010reported physical activity was assessed using the International Physical Activity Questionnaire. Biomarkers of brain pathologies comprised medial temporal lobe atrophy (MTA), white matter lesions, and plasma amyloid beta (A\u03b2)42\/40 and phosphorylated tau181. Association between physical activity and risk of developing dementia over 5 years of follow\u2010up, and interactions with biomarkers of brain pathologies were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Physical activity moderated the association between MTA and plasma A\u03b242\/40 level and increased dementia risk. Compared to participants with low physical activity, associations of both MTA and plasma A\u03b242\/40 on dementia risk were attenuated in participants with high physical activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Although reverse causality cannot be excluded, this work suggests that physical activity may contribute to cognitive reserve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Physical activity is an interesting modifiable target for dementia prevention.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Physical activity may moderate the impact of brain pathology on dementia risk.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Medial temporal lobe atrophy and plasma amyloid beta 42\/40 ratio were associated with increased dementia risk especially in those with low level of physical activity.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13360","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T20:23:58Z","timestamp":1688847838000},"page":"5700-5718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort"],"prefix":"10.1002","volume":"19","author":[{"given":"Leslie","family":"Grasset","sequence":"first","affiliation":[{"name":"University of Bordeaux Inserm Bordeaux Population Health Research Center UMR 1219, CIC1401\u2010EC  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Planche","sequence":"additional","affiliation":[{"name":"University of Bordeaux CNRS UMR 5293 Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, Centre M\u00e9moire de Ressources et de Recherches P\u00f4le de Neurosciences Cliniques CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bouteloup","sequence":"additional","affiliation":[{"name":"University of Bordeaux Inserm Bordeaux Population Health Research Center UMR 1219, CIC1401\u2010EC  Bordeaux France"},{"name":"Pole de sante publique Centre Hospitalier Universitaire (CHU) de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chabha","family":"Azouani","sequence":"additional","affiliation":[{"name":"CATI multicentre imaging platform US52\u2010UAR2031 CEA ICM SU CNRS INSERM APHP  Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dubois","sequence":"additional","affiliation":[{"name":"IM2A AP\u2010HP INSERM UMR\u2010S975 Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Institut de la M\u00e9moire et de la Maladie d'Alzheimer Institut du 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