{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:54:06Z","timestamp":1793922846113,"version":"4.8.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>As a collaboration model between the International HundredK+ Cohorts Consortium (IHCC) and the Davos Alzheimer's Collaborative (DAC), our aim was to develop a trans\u2010ethnic genomic informed risk assessment (GIRA) algorithm for Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The GIRA model was created to include polygenic risk score calculated from the AD genome\u2010wide association study loci, the apolipoprotein E haplotypes, and non\u2010genetic covariates including age, sex, and the first three principal components of population substructure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We validated the performance of the GIRA model in different populations. The proteomic study in the participant sites identified proteins related to female infertility and autoimmune thyroiditis and associated with the risk scores of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>As the initial effort by the IHCC to leverage existing large\u2010scale datasets in a collaborative setting with DAC, we developed a trans\u2010ethnic GIRA for AD with the potential of identifying individuals at high risk of developing AD for future clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13378","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T12:43:16Z","timestamp":1689338596000},"page":"5765-5772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Trans\u2010ethnic genomic informed risk assessment for Alzheimer's 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