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elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In 99 cognitive impairment patients due to AD and\/or DLB and 32 controls, 18F\u2010florbetaben (FBB) and dual\u2010phase dopamine transporter (DAT) positron emission tomography (PET) were performed to measure the FBB standardized uptake value ratio (SUVR), striatal DAT uptakes, and brain perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Higher FBB\u2010SUVR and lower ventral striatal DAT uptake were intercorrelated and, respectively, associated with left entorhinal\/temporo\u2010parietal\u2010centered hypoperfusion and vermis\/hippocampal\u2010centered hyperperfusion, whereas regional perfusion mediated clinical symptoms and cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Amyloid beta deposition and striatal dopaminergic depletion contribute to regional perfusion changes, clinical symptoms, and cognition in the spectrum of normal aging and cognitive impairment due to AD and\/or LBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Amyloid beta (A\u03b2) deposition was associated with ventral striatal dopaminergic depletion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A\u03b2 deposition and dopaminergic depletion correlated with perfusion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A\u03b2 deposition correlated with hypoperfusion centered in the left entorhinal cortex.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Dopaminergic depletion correlated with hyperperfusion centered in the vermis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Perfusion mediated the A\u03b2 deposition\/dopaminergic depletion's effects on 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