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Some studies showed an early decline, but others did not. The present study introduces evidence from a novel naming test.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Cognitively normal (<jats:italic>n<\/jats:italic>\u00a0=\u00a0138), mild cognitive impairment (MCI; <jats:italic>n<\/jats:italic>\u00a0=\u00a021), and Alzheimer's disease (AD; <jats:italic>n<\/jats:italic>\u00a0=\u00a031) groups completed an expanded Multilingual Naming Test with a time\u2010pressured administration procedure (MINT Sprint 2.0). Cerebrospinal fluid biomarkers classified participants as true controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a061) or preclinical AD (<jats:italic>n<\/jats:italic>\u00a0=\u00a026).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Total correct MINT Sprint 2.0 scores exhibited good sensitivity and specificity (&gt;0.85) for discriminating true controls from cognitively impaired (MCI\/AD) groups and showed significant differences between true controls and preclinical AD groups. Time measurement did not improve classification, but percent resolved scores exhibited promise as an independent AD marker.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Naming deficits can be detected in the earliest stages of AD with tests and procedures designed for this purpose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13381","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T04:21:48Z","timestamp":1689740508000},"page":"112-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The MINT Sprint 2.0: A picture naming test for detection of naming impairments in Alzheimer's disease and in preclinical AD"],"prefix":"10.1002","volume":"20","author":[{"given":"Tamar H.","family":"Gollan","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California, San Diego La Jolla California 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