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Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify A\u03b2 and tau pathologies in individuals segregated as cognitively unimpaired (CU) and impaired (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We assessed 138 CU and 87 CI with available plasma p\u2010tau231, 217\n                      <jats:sup>+<\/jats:sup>\n                      , and 181, A\u03b242\/40, GFAP and A\u03b2\u2010 and tau\u2010PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In CU, only plasma p\u2010tau231 and p\u2010tau217\n                      <jats:sup>+<\/jats:sup>\n                      significantly improved the performance of the demographics in detecting A\u03b2\u2010PET positivity, while no plasma biomarker provided additional information to identify tau\u2010PET positivity. In CI, p\u2010tau217\n                      <jats:sup>+<\/jats:sup>\n                      and GFAP significantly contributed to demographics to identify both A\u03b2\u2010PET and tau\u2010PET positivity, while p\u2010tau231 only provided additional information to identify tau\u2010PET positivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Our results support plasma p\u2010tau231 and p\u2010tau217\n                      <jats:sup>+<\/jats:sup>\n                      as state markers of early A\u03b2 deposition, but in later disease stages they inform on tau tangle accumulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>It is still unclear how much plasma biomarkers contribute to identification of AD pathology across the AD spectrum beyond the information already provided by demographics (age + sex).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Plasma p\u2010tau231 and p\u2010tau217\n                            <jats:sup>+<\/jats:sup>\n                            contribute to demographic information to identify brain A\u03b2 pathology in preclinical AD.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            In CI individuals, plasma p\u2010tau231 contributes to age and sex to inform on the accumulation of tau tangles, while p\u2010tau217\n                            <jats:sup>+<\/jats:sup>\n                            and GFAP inform on both A\u03b2 deposition and tau pathology.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13393","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T09:00:36Z","timestamp":1691053236000},"page":"4463-4474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Plasma p\u2010tau231 and p\u2010tau217 inform on tau tangles aggregation in cognitively impaired individuals"],"prefix":"10.1002","volume":"19","author":[{"given":"Pamela C. L.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Alzheimer's Disease Research Unit Douglas Hospital Research Institute Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tissot","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania 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L.","family":"Benedet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry The Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Povala","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Bellaver","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Graduate Program in Biological Sciences: Biochemistry Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas 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de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gallen","family":"Triana\u2010Baltzer","sequence":"additional","affiliation":[{"name":"Neuroscience Biomarkers Janssen Research and Development  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmuth","family":"Kolb","sequence":"additional","affiliation":[{"name":"Neuroscience Biomarkers Janssen Research and Development  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Alzheimer's Disease Research Unit Douglas Hospital Research Institute Le Centre int\u00e9gr\u00e9 universitaire de 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