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The overall aim was to utilize this framework to characterize pre\u2010mortem ATN status longitudinally in a clinically diagnosed cohort of dementia with Lewy bodies (DLB) and to correlate it with the <jats:italic>post mortem<\/jats:italic> diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The cohort was subtyped by cerebrospinal fluid (CSF) ATN category. A subcohort had longitudinal data, and a subgroup was neuropathologically evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We observed a significant difference in A\u03b2<jats:sub>42\/40<\/jats:sub> after 12 months in the A+T\u2212 group. <jats:italic>Post mortem<\/jats:italic> neuropathologic analyses indicated that most of the p\u2010Tau 181 positive (T+) cases also had a high Braak stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>This suggests that DLB patients who are A+ but T\u2212 may need to be monitored to determine whether they remain A+ or ever progress to T positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Some A+T\u2010 DLB subjects transition from A+ to negative after 12\u2010months.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Clinically diagnosed DLB with LBP\u2010AD (A+T+) maintain their positivity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Clinically diagnosed DLB with LBP\u2010AD (A+T+) maintain their positivity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Monitoring of the A+T\u2010 sub\u2010type of DLB may be necessary.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13398","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:19:12Z","timestamp":1695475152000},"page":"549-562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["ATN cerebrospinal fluid biomarkers in dementia with Lewy bodies: Initial results from the United States Dementia with Lewy Bodies Consortium"],"prefix":"10.1002","volume":"20","author":[{"given":"Lavanya","family":"Jain","sequence":"first","affiliation":[{"name":"Genomic Medicine Institute Cleveland Clinic Cleveland Ohio 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