{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:38:43Z","timestamp":1792712323485,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"S9","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>One goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early\u2010onset Alzheimer's disease (EOAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cerebrospinal fluid (CSF) concentrations of A\u03b21\u201040, A\u03b21\u201042, total tau (tTau), pTau181, VILIP\u20101, SNAP\u201025, neurogranin (Ng), neurofilament light chain (NfL), and YKL\u201040 were measured by immunoassay in 165 LEADS participants. The associations of biomarker concentrations with diagnostic group and standard cognitive tests were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biomarkers were correlated with one another. Levels of CSF A\u03b242\/40, pTau181, tTau, SNAP\u201025, and Ng in EOAD differed significantly from cognitively normal and early\u2010onset non\u2010AD dementia; NfL, YKL\u201040, and VILIP\u20101 did not. Across groups, all biomarkers except SNAP\u201025 were correlated with cognition. Within the EOAD group, A\u03b242\/40, NfL, Ng, and SNAP\u201025 were correlated with at least one cognitive measure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study provides a comprehensive analysis of CSF biomarkers in sporadic EOAD that can inform EOAD clinical trial design.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13399","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T23:16:05Z","timestamp":1690326965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cerebrospinal fluid biomarkers in the Longitudinal Early\u2010onset Alzheimer's Disease Study"],"prefix":"10.1002","volume":"19","author":[{"given":"Jeffrey L.","family":"Dage","sequence":"first","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Eloyan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Center for Statistical Sciences Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryanne","family":"Thangarajah","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Center for Statistical Sciences Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin B.","family":"Hammers","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Fagan","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia D.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne E.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Snoddy","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly N. 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