{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:46:17Z","timestamp":1771659977778,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Neuronal health as a potential underlying mechanism of the beneficial effects of exercise has been understudied in humans. Furthermore, there has been limited consideration of potential moderators (e.g., cardiovascular health) on the effects of exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Clinically normal middle\u2010aged and older adults completed a validated questionnaire about exercise engagement over a 10\u2010year period (<jats:italic>n<\/jats:italic>\u00a0=\u00a075; age 63\u00a0\u00b1\u00a08 years). A composite estimate of neuronal injury was formulated that included cerebrospinal fluid\u2010based measures of visinin\u2010like protein\u20101, neurogranin, synaptosomal\u2010associated protein 25, and neurofilament light chain. Cardiovascular risk was estimated using the Framingham Risk Score.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Cross\u2010sectional analyses showed that greater exercise engagement was associated with less neuronal injury in the group with lower cardiovascular risk (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), but not the group with higher cardiovascular risk (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.209).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Cardiovascular risk is an important moderator to consider when examining the effects of exercise on cognitive and neural health, and may be relevant to personalized exercise recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We examined the association between exercise engagement and neuronal injury.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Vascular risk moderated the association between exercise and neuronal injury.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cardiovascular risk may be relevant to personalized exercise recommendations.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13400","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T09:01:17Z","timestamp":1691053277000},"page":"4454-4462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of exercise engagement and cardiovascular risk on neuronal injury"],"prefix":"10.1002","volume":"19","author":[{"given":"Marta","family":"Stojanovic","sequence":"first","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences Washington University in St. Louis St. Louis Missouri USA"},{"name":"Department of Neurology Washington University in St. Louis St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne E.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis St. Louis Missouri USA"},{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University in St. Louis St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis St. Louis Missouri USA"},{"name":"Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University in St. Louis St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Head","sequence":"additional","affiliation":[{"name":"Department of Psychological &amp; 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