{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:47:37Z","timestamp":1768423657324,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2004051"],"award-info":[{"award-number":["2004051"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Finding low\u2010cost methods to detect early\u2010stage Alzheimer's disease (AD) is a research priority for neuroprotective drug development. Presymptomatic Alzheimer's is associated with gait impairment but hand motor tests, which are more accessible, have hardly been investigated. This study evaluated how home\u2010based Tasmanian (TAS) Test keyboard tapping tests predict episodic memory performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>1169 community participants (65.8\u00a0\u00b1\u00a07.4 years old; 73% female) without cognitive symptoms completed online single\u2010key and alternate\u2010key tapping tests and episodic memory, working memory, and executive function cognitive tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All single\u2010key (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:sub>adj<\/jats:sub>\u00a0=\u00a08.8%, \u0394AIC\u00a0=\u00a05.2) and alternate\u2010key (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:sub>adj<\/jats:sub>\u00a0=\u00a09.1%, \u0394AIC\u00a0=\u00a08.8) motor features predicted episodic memory performance relative to demographic and mood confounders only (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:sub>adj<\/jats:sub>\u00a0=\u00a08.1%). No tapping features improved estimation of working memory.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Brief self\u2010administered online hand movement tests predict asymptomatic episodic memory impairment. This provides a potential low\u2010cost home\u2010based method for stratification of enriched cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We devised two brief online keyboard tapping tests to assess hand motor function.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>1169 cognitively asymptomatic adults completed motor\u2010 and cognitive tests online.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Impaired hand motor function predicted reduced episodic memory performance.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This brief self\u2010administered test may aid stratification of community cohorts.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13401","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:51:46Z","timestamp":1690768306000},"page":"173-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Estimating presymptomatic episodic memory impairment using simple hand movement tests: A cross\u2010sectional study of a large sample of older adults"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2542-2026","authenticated-orcid":false,"given":"Xinyi","family":"Wang","sequence":"first","affiliation":[{"name":"Wicking Dementia Research and Education Centre University of Tasmania Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-1069","authenticated-orcid":false,"given":"Rebecca J.","family":"St 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