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Milestone symptoms were distilled to create a prototypical progression and severity scale of functional impairment: the PPA Progression Planning Aid (\u201cPPA\u2010Squared\u201d).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This work introduces a symptom\u2010led staging scheme and functional scale for semantic and non\u2010fluent\/agrammatic variants of PPA. Our findings have implications for diagnostic and care pathway guidelines, trial design, and personalized prognosis and treatment for PPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We introduce new symptom\u2010led perspectives on primary progressive aphasia (PPA).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The focus is on non\u2010fluent\/agrammatic (nfvPPA) and semantic (svPPA) variants.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Foregrounding of early and non\u2010verbal features of PPA and clinical trajectories is featured.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We introduce a symptom\u2010led staging scheme for PPA.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We propose a prototype for a functional impairment scale, the PPA Progression Planning Aid.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13415","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T04:49:07Z","timestamp":1691383747000},"page":"195-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Symptom\u2010led staging for semantic and non\u2010fluent\/agrammatic variants of primary progressive aphasia"],"prefix":"10.1002","volume":"20","author":[{"given":"Chris J. 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