{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:01:32Z","timestamp":1791478892883,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Memory\u2010associated neural circuits produce oscillatory events including theta bursts (TBs), sleep spindles (SPs), and slow waves (SWs) in sleep electroencephalography (EEG). Changes in the\u00a0\u201ccoupling\u201d of these events may indicate early Alzheimer's disease (AD) pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 205 aging adults using single\u2010channel sleep EEG, cerebrospinal fluid (CSF) AD biomarkers, and Clinical Dementia Rating\u00ae (CDR\u00ae) scale. We mapped SW\u2010TB and SW\u2010SP neural circuit coupling precision to amyloid positivity, cognitive impairment, and CSF AD biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Cognitive impairment correlated with lower TB spectral power in SW\u2010TB coupling. Cognitively unimpaired, amyloid positive individuals demonstrated lower precision in SW\u2010TB and SW\u2010SP coupling compared to amyloid negative individuals. Significant biomarker correlations were found in oscillatory event coupling with CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      , phosphorylated\u2010 tau\n                      <jats:sub>181<\/jats:sub>\n                      , and total\u2010tau.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Sleep\u2010dependent memory processing integrity\u00a0in neural circuits can be measured for both SW\u2010TB and SW\u2010SP coupling. This breakdown\u00a0associates\u00a0with amyloid positivity, increased AD pathology, and cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>At\u2010home sleep EEG is a potential biomarker of neural circuits linked to memory.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Circuit precision is associated with amyloid positivity in asymptomatic aging adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Levels of CSF amyloid and tau also correlate with circuit precision in sleep EEG.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Theta burst EEG power is decreased in very early mild cognitive impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This technique may enable inexpensive wearable EEGs for monitoring brain health.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13420","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:14:38Z","timestamp":1692774878000},"page":"301-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Rachelle L.","family":"Pulver","sequence":"first","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine Aurora Colorado USA"},{"name":"University of Colorado Alzheimer's and Cognition Center University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Kronberg","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey M.","family":"Medenblik","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine Aurora Colorado USA"},{"name":"University of Colorado Alzheimer's and Cognition Center University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly O.","family":"Kheyfets","sequence":"additional","affiliation":[{"name":"Department of Pediatric Critical Care Medicine University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto R.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine St Louis Missouri USA"},{"name":"Knight Alzheimer Disease Research Center Washington University School of Medicine St Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine St Louis Missouri USA"},{"name":"Knight Alzheimer Disease 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