{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:15:01Z","timestamp":1791983701532,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Research\u2010oriented autopsy cohorts provide critical insights into dementia pathobiology. However, different studies sometimes report disparate findings, partially because each study has its own recruitment biases. We hypothesized that a straightforward metric, related to the percentage of research volunteers cognitively normal at recruitment, would predict other inter\u2010cohort differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The National Alzheimer's Coordinating Center (NACC) provided data on\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a07178 autopsied participants from 28 individual research centers. Research cohorts were grouped based on the proportion of participants with normal cognition at initial clinical visit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Cohorts with more participants who were cognitively normal at recruitment contained more individuals who were older, female, had lower frequencies of apolipoprotein E \u03b54, Lewy body disease, and frontotemporal dementia, but higher rates of cerebrovascular disease. Alzheimer's disease (AD) pathology was little different between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The percentage of participants recruited while cognitively normal predicted differences in findings in autopsy research cohorts. Most differences were in non\u2010AD pathologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Systematic differences exist between autopsy cohorts that serve dementia research.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We propose a metric to use for gauging a research\u2010oriented autopsy cohort.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>It is essential to consider the characteristics of autopsy cohorts.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13422","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:58:48Z","timestamp":1692644328000},"page":"266-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Different cohort, disparate results: Selection bias is a key factor in autopsy cohorts"],"prefix":"10.1002","volume":"20","author":[{"given":"Kathryn","family":"Gauthreaux","sequence":"first","affiliation":[{"name":"National Alzheimer's Coordinating Center Department of Epidemiology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Kukull","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center Department of Epidemiology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin B.","family":"Nelson","sequence":"additional","affiliation":[{"name":"National Institute on Neurological Disease and Stroke, National Institutes of Health  Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mock","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center Department of Epidemiology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center Department of Epidemiology University of Washington  Seattle Washington USA"},{"name":"Department of Statistics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwun C. 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