{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:46:36Z","timestamp":1793025996903,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Almost all individuals with Down syndrome (DS) will develop neuropathological features of Alzheimer's disease (AD). Understanding AD biomarker trajectories is necessary for DS\u2010specific clinical interventions and interpretation of drug\u2010related changes in the disease trajectory.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 177 adults with DS from the Alzheimer's Biomarker Consortium\u2010Down Syndrome (ABC\u2010DS) underwent positron emission tomography (PET) and MR imaging. Amyloid\u2010beta (A\u03b2) trajectories were modeled to provide individual\u2010level estimates of A\u03b2\u2010positive (A+) chronicity, which were compared against longitudinal tau change.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Elevated tau was observed in all NFT regions following A+ and longitudinal tau increased with respect to A+ chronicity. Tau increases in NFT regions I\u2010III was observed 0\u20132.5 years following A+. Nearly all A+ individuals had tau increases in the medial temporal lobe.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>These findings highlight the rapid accumulation of amyloid and early onset of tau relative to amyloid in DS and provide a strategy for temporally characterizing AD neuropathology progression that is specific to the DS population and independent of chronological age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Longitudinal amyloid trajectories reveal rapid A\u03b2 accumulation in Down syndrome<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>NFT stage tau was strongly associated with A+ chronicity<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Early longitudinal tau increases were observed 2.5\u20135 years after reaching A+<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13444","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:24:21Z","timestamp":1693279461000},"page":"388-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Characterizing the emergence of amyloid and tau burden in Down syndrome"],"prefix":"10.1002","volume":"20","author":[{"given":"Matthew D.","family":"Zammit","sequence":"first","affiliation":[{"name":"University of Wisconsin\u2010Madison Waisman Center  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobey J.","family":"Betthauser","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison Alzheimer's Disease Research Center  Madison Wisconsin USA"},{"name":"Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin 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