{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:41:00Z","timestamp":1791384060004,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32HD007489"],"award-info":[{"award-number":["T32HD007489"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P50HD105353"],"award-info":[{"award-number":["P50HD105353"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Down syndrome (DS) is a genetic cause of early\u2010onset Alzheimer's disease (AD). The National Institute on Aging\u2013Alzheimer's Association AT(N) Research Framework is a staging model for AD biomarkers but has not been assessed in DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHOD<\/jats:title><jats:p>Data are from the Alzheimer's Biomarker Consortium\u2013Down Syndrome. Positron emission tomography (PET) amyloid beta (A\u03b2; 15 mCi of [<jats:sup>11<\/jats:sup>C]Pittsburgh compound B) and tau (10 mCi of [<jats:sup>18<\/jats:sup>F]AV\u20101451) were used to classify amyloid (A) \u2013\/+ and tau (T) +\/\u2013. Hippocampal volume classified neurodegeneration (N) \u2013\/+. The modified Cued Recall Test assessed episodic memory.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Analyses included 162 adults with DS (aged M\u00a0=\u00a038.84 years, standard deviation\u00a0=\u00a08.41). Overall, 69.8% of participants were classified as A\u2013\/T\u2013\/(N)\u2013, 11.1% were A+\/T\u2013\/(N)\u2013, 5.6% were A+\/T+\/(N)\u2013, and 9.3% were A+\/T+\/(N)+. Participants deemed cognitively stable were most likely to be A\u2013T\u2013(N)\u2013 and A+T\u2013(N)\u2013. Tau PET (T+) most closely aligning with memory impairment and AD clinical status.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Findings add to understanding of AT(N) biomarker profiles in DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Overall, 69.8% of adults with Down syndrome (DS) aged 25 to 61 years were classified as amyloid (A)\u2013\/tau (T)\u2013\/neurodegeneration (N)\u2013, 11.1% were A+\/T\u2013\/(N)\u2013, 5.6% were A+\/T+\/(N)\u2013, and 9.3% were A+\/T+\/(N)+.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The AT(N) profiles were associated with clinical Alzheimer's disease (AD) status and with memory performance, with the presence of T+ aligned with AD clinical symptomology.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Findings inform models for predicting the transition to the prodromal stage of AD in DS.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13446","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T01:29:46Z","timestamp":1693272586000},"page":"366-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome"],"prefix":"10.1002","volume":"20","author":[{"given":"Sigan L.","family":"Hartley","sequence":"first","affiliation":[{"name":"Waisman Center University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"School of Human Ecology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Handen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania 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