{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:27:09Z","timestamp":1793863629741,"version":"4.6.1"},"reference-count":75,"publisher":"Wiley","issue":"S9","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ZEN\u201021\u2010848216"],"award-info":[{"award-number":["ZEN\u201021\u2010848216"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We aimed to describe baseline amyloid\u2010beta (A\u03b2) and tau\u2010positron emission tomograrphy (PET) from Longitudinal Early\u2010onset Alzheimer's Disease Study (LEADS), a prospective multi\u2010site observational study of sporadic early\u2010onset Alzheimer's disease (EOAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed baseline [18F]Florbetaben (A\u03b2) and [18F]Flortaucipir (tau)\u2010PET from cognitively impaired participants with a clinical diagnosis of mild cognitive impairment (MCI) or AD dementia aged\u00a0&lt;\u00a065 years. Florbetaben scans were used to distinguish cognitively impaired participants with EOAD (A\u03b2+) from EOnonAD (A\u03b2\u2212) based on the combination of visual read by expert reader and image quantification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>243\/321 (75.7%) of participants were assigned to the EOAD group based on amyloid\u2010PET; 231 (95.1%) of them were tau\u2010PET positive (A+T+). Tau\u2010PET signal was elevated across cortical regions with a parietal\u2010predominant pattern, and higher burden was observed in younger and female EOAD participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>LEADS data emphasizes the importance of biomarkers to enhance diagnostic accuracy in EOAD. The advanced tau\u2010PET binding at baseline might have implications for therapeutic strategies in patients with EOAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>HIGHLIGHTS<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>72% of patients with clinical EOAD were positive on both amyloid\u2010 and tau\u2010PET.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Amyloid\u2010positive patients with EOAD had high tau\u2010PET signal across cortical regions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In EOAD, tau\u2010PET mediated the relationship between amyloid\u2010PET and MMSE.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Among EOAD patients, younger onset and female sex were associated with higher tau\u2010PET.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13453","type":"journal-article","created":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:13:53Z","timestamp":1694344433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Amyloid and tau\u2010PET in early\u2010onset AD: Baseline data from the Longitudinal Early\u2010onset Alzheimer's Disease Study (LEADS)"],"prefix":"10.1002","volume":"19","author":[{"given":"Hanna","family":"Cho","sequence":"first","affiliation":[{"name":"Memory and Aging Center UCSF Weill Institute for Neurosciences Department of Neurology University of California  San Francisco California 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