{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:45:24Z","timestamp":1781214324919,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Alzheimer's disease studies often lack ethnic diversity.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We evaluated associations between plasma biomarkers commonly studied in Alzheimer's (p\u2010tau181, GFAP, and NfL), clinical diagnosis (clinically normal, amnestic MCI, amnestic dementia, or non\u2010amnestic MCI\/dementia), and A\u03b2\u2010PET in Hispanic and non\u2010Hispanic older adults. Hispanics were predominantly of Cuban or South American ancestry.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Three\u2010hundred seventy nine participants underwent blood draw (71.9\u00a0\u00b1\u00a07.8 years old, 60.2% female, 57% Hispanic of which 88% were Cuban or South American) and 240 completed A\u03b2\u2010PET. P\u2010tau181 was higher in amnestic MCI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004, <jats:italic>d<\/jats:italic>\u00a0=\u00a00.53) and dementia (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>d<\/jats:italic>\u00a0=\u00a00.97) than in clinically normal participants and discriminated A\u03b2\u2010PET[+] and A\u03b2\u2010PET[\u2010] (AUC\u00a0=\u00a00.86). P\u2010tau181 outperformed GFAP and NfL. There were no significant interactions with ethnicity. Among amnestic MCI, Hispanics had lower odds of elevated p\u2010tau181 than non\u2010Hispanic (OR\u00a0=\u00a00.41, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Plasma p\u2010tau181 informs etiological diagnosis of cognitively impaired Hispanic and non\u2010Hispanic older adults. Hispanic ethnicity may relate to greater likelihood of non\u2010Alzheimer's contributions to memory loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Alzheimer's biomarkers were measured in Hispanic and non\u2010Hispanic older adults.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma p\u2010tau181 related to amnestic cognitive decline and brain amyloid burden.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>AD biomarker associations did not differ between Hispanic and non\u2010Hispanic ethnicity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Hispanic individuals may be more likely to have non\u2010Alzheimer causes of memory loss.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13456","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T08:00:51Z","timestamp":1693987251000},"page":"437-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Plasma Alzheimer's biomarkers and brain amyloid in Hispanic and non\u2010Hispanic older adults"],"prefix":"10.1002","volume":"20","author":[{"given":"Breton M.","family":"Asken","sequence":"first","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"Department of Clinical and Health Psychology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010En","family":"Wang","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"Department of Applied 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