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We used latent profile analysis to group participants based on behavior patterns and assessed change in cognition by group.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Three latent profiles were identified: high (<jats:italic>n<\/jats:italic>\u00a0=\u00a0183), moderate (<jats:italic>n<\/jats:italic>\u00a0=\u00a0441), and low (<jats:italic>n<\/jats:italic>\u00a0=\u00a091) engagement in health behaviors. Compared to high engagement, the moderate (mean difference [MD]\u00a0=\u00a0\u20100.02, 95% CI\u00a0=\u00a0[\u20100.03;\u20100.0002], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048) and low (MD\u00a0=\u00a0\u20100.06, 95% CI\u00a0=\u00a0[\u20100.08;\u20100.03], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) groups had faster annual rates of decline in global cognition, with no significant effects modifiers (vascular risk factors, apolipoprotein E [<jats:italic>APOE<\/jats:italic>] \u03b54, motor function).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Avoiding low levels of lifestyle health behaviors may help maintain cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Latent profile analysis (LPA) captures lifestyle health behaviors associated with cognitive function.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Such behavior include physical activity, cognitive activity, healthy diet, social activity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We used LPA to examine associations of behaviors and cognitive function over time.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Older adults with low lifestyle health behaviors showed more rapid decline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>To a lesser degree, so did those with moderate lifestyle health behaviors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Vascular conditions and risks, <jats:italic>APOE<\/jats:italic>\u03b54, or motor function did not modify the effect.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13459","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:44:17Z","timestamp":1694094257000},"page":"472-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Profiles of lifestyle 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