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This ACC hyperactivation arises from the disinhibition of local inhibitory circuits and increased excitatory inputs from the hippocampal CA1 region. Inhibiting hyperactivity in the CA1\u2010ACC circuit improved memory recall after anesthesia. Moreover, anesthesia led to increased tau phosphorylation in the hippocampus, and inhibiting this hyperphosphorylation prevented ACC hyperactivity and subsequent memory impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Hippocampal\u2010cortical hyperactivity plays a role in anesthesia\u2010induced remote memory impairment. Targeting tau hyperphosphorylation shows promise as a therapeutic strategy to mitigate anesthesia\u2010induced neural network dysfunction and retrograde amnesia in AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13464","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T08:44:25Z","timestamp":1694421865000},"page":"494-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anesthesia\u2010induced hippocampal\u2010cortical hyperactivity and tau hyperphosphorylation impair remote memory retrieval in Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Kai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Barnard College of 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