{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:15:20Z","timestamp":1770682520640,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG073442"],"award-info":[{"award-number":["R01AG073442"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Limited evidence exists on the associations of discontinuing versus continuing long\u2010term opioid therapy (LTOT) with pain intensity, physical function, and depression among patients with Alzheimer's disease and related dementias (ADRD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A cohort study among 138,059 older residents with mild\u2010to\u2010moderate ADRD and receipt of LTOT was conducted using a 100% Medicare nursing home sample. Discontinuation of LTOT was defined as no opioid refills for \u2265 60 days. Outcomes were worsening pain, physical function, and depression from baseline to quarterly assessments during 1\u2010 and 2\u2010year follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The adjusted odds of worsening pain and depressive symptoms were 29% and 5% lower at the 1\u2010year follow\u2010up and 35% and 9% lower at the 2\u2010year follow\u2010up for residents who discontinued versus continued LTOT, with no difference in physical function.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Discontinuing LTOT was associated with lower short\u2010 and long\u2010term worsening pain and depressive symptoms than continuing LTOT among older residents with ADRD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Discontinuing long\u2010term opioid therapy (LTOT) was associated with lower short\u2010 and long\u2010term worsening pain.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Discontinuing LTOT was related to lower short\u2010 and long\u2010term worsening depression.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Discontinuing LTOT was not associated with short\u2010 and long\u2010term physical function.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13489","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:01:47Z","timestamp":1697698907000},"page":"1026-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pain intensity, physical function, and depressive symptoms associated with discontinuing long\u2010term opioid therapy in older adults with Alzheimer's disease and related dementias"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-6907","authenticated-orcid":false,"given":"Yu\u2010Jung Jenny","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Outcomes and Translational Sciences College of Pharmacy The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almut G.","family":"Winterstein","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Center for Drug Evaluation and Safety University of Florida  Gainesville Florida USA"},{"name":"Department of Epidemiology Colleges of Medicine and Public Health &amp; Health Professions University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Community Health and Family Medicine College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger B.","family":"Fillingim","sequence":"additional","affiliation":[{"name":"Pain Research and Intervention Center of Excellence University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Statistics College of Liberal Arts and Sciences University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Solberg","sequence":"additional","affiliation":[{"name":"North Florida\/South Georgia Veterans Health System Malcom Randall Department of Veterans Affairs Medical Center Geriatrics Research, Education, Clinical Center (GRECC)  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven T.","family":"DeKosky","sequence":"additional","affiliation":[{"name":"Department of Neurology McKnight Brain Institute University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13536"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1225"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0306"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809243391303"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000818\u20103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.10.012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1464"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7103a1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000803"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2021.01.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2021.07.020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17\u20100598"},{"key":"e_1_2_10_15_1","unstructured":"Services CfMaM.Chronic Conditions Data Warehouse: Chronic Condition Categories. 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