{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:13:18Z","timestamp":1783977198864,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["111565741185"],"award-info":[{"award-number":["111565741185"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["#CCL40010417"],"award-info":[{"award-number":["#CCL40010417"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["#40010035"],"award-info":[{"award-number":["#40010035"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F31AG062158"],"award-info":[{"award-number":["F31AG062158"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG071074"],"award-info":[{"award-number":["R01 AG071074"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG067021"],"award-info":[{"award-number":["R01 AG067021"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG053184"],"award-info":[{"award-number":["R01 AG053184"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21 AG064413"],"award-info":[{"award-number":["R21 AG064413"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R42 AG069629"],"award-info":[{"award-number":["R42 AG069629"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21 AG070877"],"award-info":[{"award-number":["R21 AG070877"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG054671"],"award-info":[{"award-number":["R01 AG054671"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG077627"],"award-info":[{"award-number":["RF1AG077627"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23 AG058805"],"award-info":[{"award-number":["K23 AG058805"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG078191"],"award-info":[{"award-number":["R01AG078191"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Depressive symptoms are among early behavioral changes in Alzheimer's disease (AD); however, the relationship between neurodegeneration and depressive symptoms remains inconclusive. To better understand this relationship in preclinical AD, we examined hippocampal volume and depressive symptoms in cognitively unimpaired carriers of the presenilin\u20101 (<jats:italic>PSEN1<\/jats:italic>) E280A mutation for autosomal dominant AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 27 <jats:italic>PSEN1<\/jats:italic> mutation carriers and 26 non\u2010carrier family members were included. Linear regression was used to test the relationship between hippocampal volume and 15\u2010item Geriatric Depression Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Carriers and non\u2010carriers did not differ in depressive symptoms or hippocampal volume. Within carriers, lower hippocampal volume was associated with greater depressive symptoms, which remained significant after adjusting for age and cognition. This relationship was not significant in non\u2010carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Hippocampal neurodegeneration may underlie depressive symptoms in preclinical autosomal dominant AD. These findings provide support for the utility of targeting depressive symptoms in AD prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We compared unimpaired autosomal dominant Alzheimer's disease (AD) mutation carriers and non\u2010carriers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Carriers and non\u2010carriers did not differ in severity of depressive symptoms.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In carriers, hippocampal volume was inversely associated with depressive symptoms.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Depressive symptoms may be a useful target in AD prevention.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13501","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:58:07Z","timestamp":1697281087000},"page":"986-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Stephanie","family":"Langella","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Lopera","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia  Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Baena","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia  Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.","family":"Fox\u2010Fuller","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychological and Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Munera","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo E.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychological and Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Averi","family":"Giudicessi","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychological and Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Vannini","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Hanseeuw","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Cliniques Universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad A.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakeel T.","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia  Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Gatchel","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"McLean Hospital Harvard Medical School  Belmont Massachusetts USA"},{"name":"Department of Psychiatry Baylor College of Medicine  Houston Texas USA"},{"name":"Mental Health Care Line MEDVAMC  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.137.4.439"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.10.1193"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010020\u20100839\u20101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102012\u2010111922"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.86"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181b0fa13"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610203009591"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.04.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17040442"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.8964"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12626"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.6.2001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.3314"},{"key":"e_1_2_8_17_1","first-page":"1957","article-title":"Reviews and overviews hippocampal volume and depression\u202f: a meta\u2010analysis of MRI studies","volume":"161","author":"Videbech P","year":"2004","journal-title":"Hippocampal Vol Depress A meta\u2010Analysis MRI Stud"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.80"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.271"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442\u2010200201000\u201000008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.11.2081"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010142940"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010016\u20100928\u20100"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00040"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2018.1432030"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010022\u201001772\u20108"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170041"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(10)70323\u20109"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010221294"},{"issue":"4","key":"e_1_2_8_30_1","first-page":"653","article-title":"Functional assessment staging (FAST)","volume":"24","author":"Reisberg B","year":"1988","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.33588\/rn.4511.2007086"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000205512"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(82)90033\u20104"},{"issue":"5","key":"e_1_2_8_35_1","first-page":"53","article-title":"Validaci\u00f3n de la Escala de Depresi\u00f3n de Yesavage (versi\u00f3n reducida) en adultos mayores colombianos","volume":"1","author":"Bacca AM","year":"2005","journal-title":"Pensam Psicol\u00f3gico"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010244X\u201012\u2010181"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.118307"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.899158"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12010"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.22379\/2422402225"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.14482\/sun.34.2.362.29"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.15446\/rsap.v17n2.41295"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972\u20102327.104323"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.27"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000629"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2020.01.012"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16030319"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201095206\u20100"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30367\u20106"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.13501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:56:06Z","timestamp":1759946166000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,14]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/alz.13501"],"URL":"https:\/\/doi.org\/10.1002\/alz.13501","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,14]]},"assertion":[{"value":"2023-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}