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The neurobiological factors underlying the more rapid cognitive decline in AD in females remain unclear. This study explored how sex\u2010dependent alterations in hippocampal connectivity over 2 years are associated with cerebrovascular and amyloid pathologies in normal aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010three females and 21 males 65 to 93 years of age with no cognitive impairment performed a face\u2010name associative memory functional magnetic resonance imaging (fMRI) task with a 2\u2010year follow\u2010up. We acquired baseline carbon 11\u2010labeled Pittsburgh compound B ([\n                      <jats:sup>11<\/jats:sup>\n                      C]PiB) positron emission tomography (PET) and T2\u2010weighted fluid\u2010attenuated inversion recovery (T2\u2010FLAIR) MRI to quantify amyloid \u03b2 (A\u03b2) burden and white matter hyperintensity (WMH) volume, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Males had increased hippocampal\u2010prefrontal connectivity over 2 years, associated with greater A\u03b2 burden. Females had increased bilateral hippocampal functional connectivity, associated with greater WMH volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings suggest sex\u2010dependent compensatory mechanisms in the memory network in the presence of cerebrovascular and AD pathologies and may explain the accelerated trajectory of cognitive decline in females.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13503","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:00:10Z","timestamp":1697072410000},"page":"914-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sex\u2010dependent alterations in hippocampal connectivity are linked to cerebrovascular and amyloid pathologies in normal aging"],"prefix":"10.1002","volume":"20","author":[{"given":"Noah","family":"Schweitzer","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lopresti","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Klunk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Snitz","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Tudorascu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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