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On the other hand, lower DS Mental Status Examination memory scores were associated with higher PRS, independent of intellectual disability and\n APOE<\/jats:italic>\n (PRS including\n APOE<\/jats:italic>\n , PRS\n \n APOE<\/jats:sub>\n <\/jats:italic>\n ,\n p<\/jats:italic>\n \u00a0=\u00a02.84\u00a0\u00d7\u00a010\n \u22124<\/jats:sup>\n ; PRS excluding\n APOE<\/jats:italic>\n , PRS\n \n nonAPOE<\/jats:sub>\n <\/jats:italic>\n ,\n p<\/jats:italic>\n \u00a0=\u00a01.60\u00a0\u00d7\u00a010\n \u22122<\/jats:sup>\n ). PRS\n \n APOE<\/jats:sub>\n <\/jats:italic>\n exhibited significant associations with A\u03b242, tTau, pTau, and A\u03b242\/40 ratio in DS.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n These data indicate that the AD genetic architecture influences cognitive and CSF phenotypes in DS adults, supporting common pathways that influence memory decline in both traits.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Examination of the polygenic risk of AD in DS presented here is the first of its kind.<\/jats:p>\n <\/jats:list-item>\n \n \n AD PRS influences memory aspects in DS individuals, independently of\n APOE genotype<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n These results point to an overlap between the genes and pathways that leads to AD and those that influence dementia and memory decline in the DS population.<\/jats:p>\n <\/jats:list-item>\n \n APOE \u03b54 is linked to DS cognitive decline, expanding cognitive insights in adults.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.13506","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T08:29:24Z","timestamp":1697704164000},"page":"1038-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome"],"prefix":"10.1002","volume":"20","author":[{"given":"Priyanka","family":"Gorijala","sequence":"first","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine St. Louis Missouri USA"},{"name":"Neurogenomics and Informatics Center Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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