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However, the genetic underpinnings of this sex difference in memory performance remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We conducted the largest sex\u2010aware genetic study on late\u2010life memory to date (\n                      <jats:italic>N<\/jats:italic>\n                      <jats:sub>males<\/jats:sub>\n                      \u00a0=\u00a011,942;\n                      <jats:italic>N<\/jats:italic>\n                      <jats:sub>females<\/jats:sub>\n                      \u00a0=\u00a015,641). Leveraging harmonized memory composite scores from four cohorts of cognitive aging and AD, we performed sex\u2010stratified and sex\u2010interaction genome\u2010wide association studies in 24,216 non\u2010Hispanic White and 3367 non\u2010Hispanic Black participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We identified three sex\u2010specific loci (rs67099044\u2014\n                      <jats:italic>CBLN2<\/jats:italic>\n                      , rs719070\u2014\n                      <jats:italic>SCHIP1\/IQCJ\u2010SCHIP)<\/jats:italic>\n                      , including an X\u2010chromosome locus (rs5935633\u2014\n                      <jats:italic>EGL6\/TCEANC\/OFD1<\/jats:italic>\n                      ), that associated with memory. Additionally, we identified heparan sulfate signaling as a sex\u2010specific pathway and found sex\u2010specific genetic correlations between memory and cardiovascular, immune, and education traits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This study showed memory is highly and comparably heritable across sexes, as well as highlighted novel sex\u2010specific genes, pathways, and genetic correlations that related to late\u2010life memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Demonstrated the heritable component of late\u2010life memory is similar across sexes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Identified two genetic loci with a sex\u2010interaction with baseline memory.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Identified an X\u2010chromosome locus associated with memory decline in females.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Highlighted sex\u2010specific candidate genes and pathways associated with memory.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Revealed sex\u2010specific shared genetic architecture between memory and complex traits.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13507","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:18:29Z","timestamp":1700587109000},"page":"1250-1267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Sex\u2010specific genetic architecture of late\u2010life memory performance"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-3999","authenticated-orcid":false,"given":"Jaclyn M.","family":"Eissman","sequence":"first","affiliation":[{"name":"Vanderbilt Memory &amp; 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Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Bush","sequence":"additional","affiliation":[{"name":"Cleveland Institute for Computational Biology Department of Population and Quantitative Health Sciences Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Kunkle","sequence":"additional","affiliation":[{"name":"John P. 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