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However, they require replication in other ethnicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We performed GWAS on sporadic Alzheimer's disease (AD) including 539 patients and 854 controls from Argentina and Chile. We combined our results with those from the European Alzheimer and Dementia Biobank (EADB) in a meta\u2010analysis and tested their genetic risk score (GRS) performance in this admixed population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We detected apolipoprotein E \u03b54 as the single genome\u2010wide significant signal (odds ratio \u00a0=\u00a02.93 [2.37\u20133.63],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a02.6\u00a0\u00d7\u00a010\n                      <jats:sup>\u221223<\/jats:sup>\n                      ). The meta\u2010analysis with EADB summary statistics revealed four new loci reaching GWAS significance. Functional annotations of these loci implicated endosome\/lysosomal function. Finally, the AD\u2010GRS presented a similar performance in these populations, despite the score diminished when the Native American ancestry rose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We report the first GWAS on AD in a population from South America. It shows shared genetics modulating AD risk between the European and these admixed populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>This is the first genome\u2010wide association study on Alzheimer's disease (AD) in a population sample from Argentina and Chile.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Trans\u2010ethnic meta\u2010analysis reveals four new loci involving lysosomal function in AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            This is the first independent replication for\n                            <jats:italic>TREM2L<\/jats:italic>\n                            ,\n                            <jats:italic>IGH\u2010gene\u2010cluster<\/jats:italic>\n                            , and\n                            <jats:italic>ADAM17<\/jats:italic>\n                            loci.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A genetic risk score (GRS) developed in Europeans performed well in this population.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The higher the Native American ancestry the lower the GRS values.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13522","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:48:08Z","timestamp":1700588888000},"page":"1298-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The first genome\u2010wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-9955","authenticated-orcid":false,"given":"Maria Carolina","family":"Dalmasso","sequence":"first","affiliation":[{"name":"Studies in Neuroscience and Complex Systems Unit\u2010CONICET\u2010HEC\u2010UNAJ  Florencio Varela Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"de Rojas","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona \u2013 Universitat Internacional de Catalunya Barcelona Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases National Institute of Health Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natividad","family":"Olivar","sequence":"additional","affiliation":[{"name":"Center of Neuropsychiatry and Neurology of Behavior School of Medicine University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Muchnik","sequence":"additional","affiliation":[{"name":"Center of Neuropsychiatry and Neurology of Behavior School of Medicine University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Angel","sequence":"additional","affiliation":[{"name":"Public Health Nutrition Unit Institute of Nutrition and Food Technology University of Chile Santiago Chile"},{"name":"Interuniversity Center for Healthy Aging RED21993 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Gloger","sequence":"additional","affiliation":[{"name":"Biomedica Research Group Centro de Estudios Cl\u00ednicos Santiago Chile"},{"name":"Departamento de Psiquiatr\u00eda y Salud Mental Campus Oriente, Facultad de Medicina Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Soledad","family":"Sanchez Abalos","sequence":"additional","affiliation":[{"name":"Servicio de Diabetes y Metabolismo Hospital Regional de Ushuaia  Ushuaia Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Biomedica Research Group Centro de Estudios Cl\u00ednicos Santiago 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