{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:53:26Z","timestamp":1792068806096,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2017\u201000915"],"award-info":[{"award-number":["#2017\u201000915"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2022\u201000732"],"award-info":[{"award-number":["#2022\u201000732"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF\u201021\u2010850325"],"award-info":[{"award-number":["AARF\u201021\u2010850325"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG052521"],"award-info":[{"award-number":["AG052521"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37 AG023651"],"award-info":[{"award-number":["R37 AG023651"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG066468"],"award-info":[{"award-number":["P30 AG066468"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG025204"],"award-info":[{"award-number":["P01AG025204"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG025516"],"award-info":[{"award-number":["RF1AG025516"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG052525"],"award-info":[{"award-number":["RF1AG052525"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG052446"],"award-info":[{"award-number":["R01AG052446"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG052446"],"award-info":[{"award-number":["R01AG052446"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Detection of Alzheimer's disease (AD) pathophysiology among individuals with mild cognitive changes\u00a0and those experiencing subjective cognitive decline (SCD) remains challenging. Plasma phosphorylated tau 217 (p\u2010tau217) is one of the most promising of the emerging biomarkers for AD. However, accessible methods are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We employed a novel p\u2010tau217 immunoassay (University of Gothenburg [UGOT] p\u2010tau217) in four independent cohorts (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0308) including a cerebrospinal fluid (CSF) biomarker\u2010classified cohort (Discovery), two cohorts consisting mostly of cognitively unimpaired (CU) and mild cognitively impaired (MCI) participants (MYHAT and Pittsburgh), and a population\u2010based cohort of individuals with SCD (Barcelona\u03b2eta Brain Research Center's Alzheimer's At\u2010Risk Cohort [\u03b2\u2010AARC]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>UGOT p\u2010tau217 showed high accuracy (area under the curve [AUC]\u00a0=\u00a00.80\u20130.91) identifying amyloid beta (A\u03b2) pathology, determined either by A\u03b2 positron emission tomography or CSF A\u03b242\/40 ratio. In individuals experiencing SCD, UGOT p\u2010tau217 showed high accuracy identifying those with a positive CSF A\u03b242\/40 ratio (AUC\u00a0=\u00a00.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>UGOT p\u2010tau217 can be an easily accessible and efficient way to screen and monitor patients with suspected AD pathophysiology, even in the early stages of the continuum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13525","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:42:31Z","timestamp":1700260951000},"page":"1239-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["A novel ultrasensitive assay for plasma p\u2010tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7897-9456","authenticated-orcid":false,"given":"Fernando","family":"Gonzalez\u2010Ortiz","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela C. L.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Gonz\u00e1lez\u2010Escalante","sequence":"additional","affiliation":[{"name":"Barcelona<i>\u03b2<\/i>eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Montoliu\u2010Gaya","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ortiz\u2010Romero","sequence":"additional","affiliation":[{"name":"Barcelona<i>\u03b2<\/i>eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemyslaw R.","family":"Kac","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Turton","sequence":"additional","affiliation":[{"name":"Bioventix Plc 7 Romans Business Park  Farnham Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hlin","family":"Kvartsberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg  Gothenburg Sweden"},{"name":"King's College London Institute of Psychiatry Psychology and Neuroscience Maurice Wohl Clinical Neuroscience Institute  London UK"},{"name":"NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology Queen Square  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases Clear Water Bay  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Harrison","sequence":"additional","affiliation":[{"name":"Bioventix Plc 7 Romans Business Park  Farnham Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Bellaver","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Povala","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharick A.","family":"Pascoal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Neurology, School of Medicine University of Pittsburgh  Pittsburgh USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ganguli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Epidemiology School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Minguillon","sequence":"additional","affiliation":[{"name":"Barcelona<i>\u03b2<\/i>eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Contador","sequence":"additional","affiliation":[{"name":"Barcelona<i>\u03b2<\/i>eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Cognitive Decline and Movement Disorders Unit Neurology Department Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Su\u00e1rez\u2010Calvet","sequence":"additional","affiliation":[{"name":"Barcelona<i>\u03b2<\/i>eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"},{"name":"Cognitive Decline and Movement Disorders Unit Neurology Department Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Karikari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12638"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000605\u20108"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010022\u201000665\u20102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.02.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12447"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001925\u2010w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.263195"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2850"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51529"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000386"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.1509"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30071\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010021\u201002275\u20106"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12134"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.3671"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12841"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002074\u2010w"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa329"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001005\u20108"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114022"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015436\u20100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.09.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181cdee4f"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.980151"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.669490"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201401"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/hyb.1999.18.183"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00179"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac407"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000405\u20101"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad057"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.13525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:57:10Z","timestamp":1759946230000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,17]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/alz.13525"],"URL":"https:\/\/doi.org\/10.1002\/alz.13525","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.09.26.23296134","asserted-by":"object"}]},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,17]]},"assertion":[{"value":"2023-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}