{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:42:33Z","timestamp":1792003353192,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We assessed TAR DNA\u2010binding protein 43 (TDP\u201043) seeding activity and aggregates detection in olfactory mucosa of patients with frontotemporal lobar degeneration with TDP\u201043\u2010immunoreactive pathology (FTLD\u2010TDP) by TDP\u201043 seeding amplification assay (TDP43\u2010SAA) and immunocytochemical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The TDP43\u2010SAA was optimized using frontal cortex samples from 16 post mortem cases with FTLD\u2010TDP, FTLD with tau inclusions, and controls. Subsequently, olfactory mucosa samples were collected from 17 patients with FTLD\u2010TDP, 15 healthy controls, and three patients carrying\n                      <jats:italic>MAPT<\/jats:italic>\n                      variants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      TDP43\u2010SAA discriminated with 100% accuracy post mortem cases presenting or lacking TDP\u201043 neuropathology. TDP\u201043 seeding activity was detectable in the olfactory mucosa, and 82.4% of patients with FTLD\u2010TDP tested positive, whereas 86.7% of controls tested negative (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Two out of three patients with\n                      <jats:italic>MAPT<\/jats:italic>\n                      mutations tested negative. In TDP43\u2010SAA positive samples, cytoplasmatic deposits of phosphorylated TDP\u201043 in the olfactory neural cells were detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>TDP\u201043 aggregates can be detectable in olfactory mucosa, suggesting that TDP43\u2010SAA might be useful for identifying and monitoring FTLD\u2010TDP in living patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13541","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T02:15:12Z","timestamp":1698804912000},"page":"1156-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Detection of TDP\u201043 seeding activity in the olfactory mucosa from patients with frontotemporal dementia"],"prefix":"10.1002","volume":"20","author":[{"given":"Elena","family":"Fontana","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Bongianni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Benussi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"},{"name":"Department of Continuity of Care and Frailty ASST Spedali Civili Brescia Hospital  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Bronzato","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement 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