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These were compared with groups from 159 non\u2010AD (amyloid \u201cnegative\u201d) patients partitioned using cortical thickness, and groups in 98 patients with <jats:italic>ante mortem<\/jats:italic> MRI and <jats:italic>post mortem<\/jats:italic> tissue for measuring N and T, respectively. We applied the initial T\u2010N residual model to classify 71 patients in an independent cohort into predefined groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>AD groups displayed spatial T\u2010N <jats:italic>mismatch<\/jats:italic> patterns resembling neurodegeneration patterns in non\u2010AD groups, similarly associated with non\u2010AD factors and diverging cognitive outcomes. In the autopsy cohort, limbic T\u2010N mismatch correlated with TDP\u201043 co\u2010pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>T\u2010N <jats:italic>mismatch<\/jats:italic> may provide a personalized approach for determining non\u2010AD factors associated with resilience\/vulnerability in AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13559","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T03:19:16Z","timestamp":1701746356000},"page":"1586-1600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tau\u2010neurodegeneration <i>mismatch<\/i> reveals vulnerability and resilience to comorbidities in Alzheimer's continuum"],"prefix":"10.1002","volume":"20","author":[{"given":"Xueying","family":"Lyu","sequence":"first","affiliation":[{"name":"Departments of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Tran","family":"Duong","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Xie","sequence":"additional","affiliation":[{"name":"Departments of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"de Flores","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Caen Normandie, INSERM UMRS U1237  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyujoon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Departments of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E. 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