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In recent decades, the traditional view of the thalamus as a relay station and \u201cgateway to the cortex\u201d has expanded in recognition of its role as a central integrator of inputs from sensory systems, cortex, basal ganglia, limbic systems, brain stem nuclei, and cerebellum. As such, the thalamus is critical for numerous aspects of human cognition, mood, and behavior, as well as serving sensory processing and motor functions. Thalamus pathology is an important contributor to cognitive and functional decline, and it might be argued that the thalamus has been somewhat overlooked as an important player in dementia. In this review, we provide a comprehensive overview of thalamus anatomy and function, with an emphasis on human cognition and behavior, and discuss emerging insights on the role of thalamus pathology in dementia.<\/jats:p>","DOI":"10.1002\/alz.13563","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T15:49:13Z","timestamp":1701532153000},"page":"2209-2222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-2148","authenticated-orcid":false,"given":"J. 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