{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:26:32Z","timestamp":1792092392295,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We investigated associations of Alzheimer's disease (AD) serum biomarkers with longitudinal changes in cognitive function from mid\u2010 to late life among women.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The study population included 192 women with the median age of 53.3 years at baseline, from the Study of Women's Health Across the Nation Michigan Cohort, followed up over 14 years. Associations between baseline serum amyloid \u03b2 (A\u03b2)42, the A\u03b242\/40 ratio, phosphorylated tau181 (p\u2010tau181), and total tau with longitudinal changes in cognition were evaluated using linear mixed effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After adjusting for confounders, lower A\u03b242\/40 ratios were associated with faster declines in the Digit Span Backward Test. Higher p\u2010tau181 also showed a borderline statistically significant association with more rapid decline in the Symbol Digit Modalities Test.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our findings suggest that mid\u2010life serum AD biomarkers could be associated with accelerated cognitive decline from mid\u2010 to late life in women. Future studies with larger samples are needed to validate and extend our findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>This study investigates midlife serum AD biomarkers on longitudinal cognitive function changes in women.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Mid\u2010life serum AD biomarkers are associated with accelerated cognitive decline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A decrease in the A\u03b242\/40 ratio was associated with a faster decline in the DSB score.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A higher p\u2010tau181 concentration was associated with a faster decline in the SDMT score.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13583","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T07:02:29Z","timestamp":1703142149000},"page":"1807-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Blood\u2010based biomarkers for Alzheimer's disease and cognitive function from mid\u2010 to late life"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0851-6605","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Bakulski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health University of Michigan  Ann Arbor Michigan USA"},{"name":"Michigan Alzheimer's Disease Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Karvonen\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Environmental Health Sciences School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience College of Human Medicine Grand Rapids Research Center Michigan State University  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Albin","sequence":"additional","affiliation":[{"name":"Michigan Alzheimer's Disease Center University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"},{"name":"Neurology Service &amp; 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