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We identified and validated a magnetic resonance imaging (MRI) signature for Alzheimer's disease (AD) and related dementias (ARDR).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>An MRI ADRD signature was derived from cortical thickness maps in Framingham Heart Study (FHS) participants with AD dementia and matched controls. The signature was related to the risk of ADRD and cognitive function in FHS. Results were replicated in the University of California Davis Alzheimer's Disease Research Center (UCD\u2010ADRC) cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Participants in the bottom quartile of the signature had more than three times increased risk for ADRD compared to those in the upper three quartiles (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Greater thickness in the signature was related to better general cognition (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and episodic memory (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Results replicated in UCD\u2010ADRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>We identified a robust neuroimaging biomarker for persons at increased risk of ADRD. Other cohorts will further test the validity of this biomarker.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13600","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T12:14:00Z","timestamp":1703592840000},"page":"1881-1893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A novel neuroimaging signature for ADRD risk stratification in the community"],"prefix":"10.1002","volume":"20","author":[{"given":"Claudia L.","family":"Satizabal","sequence":"first","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases University of Texas Health Sciences Center  San Antonio Texas USA"},{"name":"Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"The Framingham Heart Study  Framingham Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa S.","family":"Beiser","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"The Framingham Heart Study  Framingham Massachusetts USA"},{"name":"Department of Biostatistics Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Fletcher","sequence":"additional","affiliation":[{"name":"IDeA Laboratory Department of Neurology University of California Davis  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases University of Texas Health Sciences Center  San Antonio Texas USA"},{"name":"Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"The Framingham Heart Study  Framingham Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"IDeA Laboratory Department of Neurology University of California Davis  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"OrtmanJM VelkoffVA HoganH.An Aging Nation: the Older Population in the United States.Current Population Reports Washington DC: US Census Bureau.2014:p25\u20101140."},{"key":"e_1_2_8_3_1","unstructured":"Bureau USC. 2017 National Population Projections Datasets. 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