{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:42:16Z","timestamp":1789512136685,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHOD<\/jats:title><jats:p>We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same\u2010age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13602","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T13:58:58Z","timestamp":1703253538000},"page":"1827-1838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project"],"prefix":"10.1002","volume":"20","author":[{"given":"Yi","family":"Su","sequence":"first","affiliation":[{"name":"Banner Alzheimer's Institute and Arizona Alzheimer's Consortium  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary","family":"Protas","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute and Arizona Alzheimer's Consortium  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Luo","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute and Arizona Alzheimer's Consortium  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute and Arizona Alzheimer's Consortium  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Alosco","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Alzheimer's Disease Research Center Boston University CTE Center Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine, Mayo Clinic Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Balcer","sequence":"additional","affiliation":[{"name":"Departments of Neurology NYU Grossman School of Medicine  New York New York USA"},{"name":"Department of Population Health and Ophthalmology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bernick","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lou Ruvo Center for Brain Health  Las Vegas Nevada USA"},{"name":"Department of Neurology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhoda","family":"Au","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Alzheimer's Disease Research Center Boston University CTE Center Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Framingham Heart Study  Framingham Massachusetts USA"},{"name":"Slone Epidemiology Center; Departments of Anatomy &amp; Neurobiology, Neurology, and Medicine Department of Epidemiology Boston University Chobanian &amp; Avedisian School of Medicine; Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Banks","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience and Psychiatry University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Barr","sequence":"additional","affiliation":[{"name":"Departments of Neurology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Radiology Psychiatry Neuroimaging Laboratory Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dodick","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine, Mayo Clinic Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas I.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Alzheimer's Disease Research Center Boston University CTE Center Boston University Chobanian &amp; 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Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Framingham Heart Study  Framingham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Daneshvar","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation Massachusetts General Hospital, Spaulding Rehabilitation Hospital, Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph N.","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Biostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine R.","family":"Peskind","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences VA Northwest Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System; University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Robert W.","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Clinical Research &amp; Leadership The George Washington University School of Medicine &amp; Health Sciences  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer V.","family":"Wethe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic School of Medicine, Mayo Clinic Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Rabinovici","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Johnson","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging, Mass General Research Institute, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorghos","family":"Tripodis","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Alzheimer's Disease Research Center Boston University CTE Center Boston University Chobanian &amp; 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