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We pooled prevalence estimates using random\u2010effects models where possible, or presented a narrative synthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We included 85 studies (<jats:italic>n<\/jats:italic> = 47,743, mean age = 44\u00b75 years). 52\/85 reported poolable estimates. SVD prevalence in populations exposed to carbon monoxide was 81%(95% CI = 60\u201093%; <jats:italic>n<\/jats:italic> = 1373; results unchanged in meta\u2010regression), carbon disulfide73% (95% CI = 54\u201087%; <jats:italic>n<\/jats:italic> = 131), 1,2\u2010dichloroethane 88% (95% CI = 4\u2010100%, <jats:italic>n<\/jats:italic> = 40), toluene 82% (95% CI = 3\u2010100%, <jats:italic>n<\/jats:italic> = 64), high altitude 49% (95% CI = 38\u201060%; <jats:italic>n<\/jats:italic> = 164),and diving 24% (95% CI = 5\u201067%, <jats:italic>n<\/jats:italic> = 172). We narratively reviewed vascular dementia studies and contact sport, lead, military, pesticide, and solvent exposures as estimates were too few\/varied to pool.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>SVD and vascular dementia may be associated with occupational\/domestic exposure to hazardous substances. 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