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Our objective was to evaluate plasma biomarkers of AD and their association with positron emission tomography (PET) biomarkers of amyloid and tau deposition in the continuum of DLB, starting from prodromal stages of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The cohort included patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD), mild cognitive impairment with Lewy bodies (MCI\u2010LB), or DLB, with a concurrent blood draw and PET scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Abnormal levels of plasma glial fibrillary acidic protein (GFAP) were found at the prodromal stage of MCI\u2010LB in association with increased amyloid PET. Abnormal levels of plasma phosphorylated tau (p\u2010tau)\u2010181 and neurofilament light (NfL) were found at the DLB stage. Plasma p\u2010tau\u2010181 showed the highest accuracy in detecting abnormal amyloid and tau PET in patients with DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The range of AD co\u2010pathology can be detected with plasma biomarkers in the DLB continuum, particularly with plasma p\u2010tau\u2010181 and GFAP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13653","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T07:00:24Z","timestamp":1707375624000},"page":"2485-2496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Plasma biomarkers of Alzheimer's disease in the continuum of dementia with Lewy bodies"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-5585","authenticated-orcid":false,"given":"Patricia","family":"Diaz\u2010Galvan","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic  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