{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:05:21Z","timestamp":1789038321874,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013301","name":"Parkinson's Foundation","doi-asserted-by":"publisher","award":["PF\u2010PRF\u2010934916"],"award-info":[{"award-number":["PF\u2010PRF\u2010934916"]}],"id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Lewy body disease, a frequently observed co\u2010pathology in Alzheimer's disease (AD), can be identified\n                      <jats:italic>antemortem<\/jats:italic>\n                      in cerebrospinal fluid (CSF) by \u03b1\u2010synuclein seed amplification assay (\u03b1S\u2010SAA). The prevalence and clinical impact of CSF \u03b1S\u2010SAA positivity in AD are still unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\u03b1S\u2010SAA was performed on CSF samples from 240 AD patients (preclinical, prodromal, and dementia stages), 85 controls, 84 patients with Parkinson's disease (PD), and 21 patients with PD with dementia or dementia with Lewy bodies. In AD patients, associations between \u03b1S\u2010SAA positivity and cognitive changes were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In agreement with available neuropathological studies, \u03b1S\u2010SAA positivity was observed in 30% of AD patients (vs 9% in controls), and was associated with cognitive decline, visuospatial impairment, and behavioral disturbances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\u03b1S\u2010SAA positivity in AD patients reflects the prevalence observed in neuropathological series and is associated with a worse clinical outcome. These data confirm the validity of CSF \u03b1S\u2010SAA positivity as biomarker of synucleinopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13658","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T07:00:15Z","timestamp":1707289215000},"page":"2444-2452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Investigating alpha\u2010synuclein co\u2010pathology in Alzheimer's disease by means of cerebrospinal fluid alpha\u2010synuclein seed amplification assay"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-5650","authenticated-orcid":false,"given":"Giovanni","family":"Bellomo","sequence":"first","affiliation":[{"name":"Center for Memory Disturbances Lab of Clinical Neurochemistry Section of Neurology Department of Medicine and Surgery University of Perugia Perugia 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