{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:51:20Z","timestamp":1789275080740,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Mapping of microscopic changes in the perivascular space (PVS) of the cerebral cortex, beyond magnetic resonance\u2010visible PVS in white matter, may enhance our ability to diagnose Alzheimer's disease (AD) early.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We used the cerebrospinal fluid (CSF) water fraction (CSFF), a magnetic resonance imaging\u2013based biomarker, to characterize brain parenchymal CSF water, reflecting microscopic PVS in parenchyma. We measured CSFF and amyloid beta (A\u03b2) using\n                      <jats:sup>11<\/jats:sup>\n                      C Pittsburgh compound B positron emission tomography to investigate their relationship at both the subject and voxel levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Our research has demonstrated a positive correlation between the parenchymal CSFF, a non\u2010invasive imaging biomarker indicative of parenchymal glymphatic clearance, and A\u03b2 deposition, observed at both individual and voxel\u2010based assessments in the posterior cingulate cortex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This study shows that an increased parenchymal CSFF is associated with A\u03b2 deposition, suggesting that CSFF could serve as a biomarker for brain glymphatic clearance, which can be used to detect early fluid changes in PVS predisposing individuals to the development of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Cerebrospinal fluid fraction (CSFF) could be a biomarker of parenchymal perivascular space.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CSFF is positively associated with amyloid beta (A\u03b2) deposition at subject level.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CSFF in an A\u03b2+ region is higher than in an A\u03b2\u2013 region in the posterior cingulate cortex.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Correspondence is found between A\u03b2 deposition and glymphatic clearance deficits measured by CSFF.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13659","type":"journal-article","created":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T07:04:26Z","timestamp":1704611066000},"page":"2047-2057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET"],"prefix":"10.1002","volume":"20","author":[{"given":"Liangdong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute (BHII) Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiology MRI Research Institute (MRIRI) Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria C.","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute (BHII) Weill Cornell Medicine  New York New York USA"},{"name":"Department of Radiology Division of Neuroradiology Weill Cornell Medicine New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyuan H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute (BHII) Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute (BHII) Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute (BHII) Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily B.","family":"Tanzi","sequence":"additional","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute (BHII) Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy A.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute (BHII) Weill Cornell Medicine  New York New York 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