{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:28:34Z","timestamp":1792189714881,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL093086"],"award-info":[{"award-number":["R01HL093086"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50AG005136"],"award-info":[{"award-number":["P50AG005136"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AG057821"],"award-info":[{"award-number":["K01AG057821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Identification of Alzheimer's disease (AD) needs inexpensive, noninvasive biomarkers, with validation in all populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We collected plasma markers in older American Indian individuals: phosphorylated\u2010tau181 (pTau181); amyloid\u2010beta (A\u03b2) 40,42; glial fibrillary acidic protein (GFAP); and neurofilament light chain (NfL). Plasma markers were analyzed for discriminant properties with cognitive status and etiology using receiver operating characteristic (ROC) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>PTau181, GFAP, NfL plasma values were significantly associated with cognition, but A\u03b2 were not. Discriminant performance was moderate for individual markers, with pTau181, GFAP, NfL performing best, but an empirically selected panel of markers (age, sex, education, pTau181, GFAP, NfL, A\u03b24240 ratio) had excellent discriminant performance (AUC\u00a0&gt;\u00a00.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>In American Indian individuals, pTau181 and A\u03b2 values suggested more common pathology than in majority populations. A\u03b2 was less informative than in other populations; however, all four markers were needed for a best\u2010performing dementia diagnostic model. These data validate utility of AD plasma markers, while suggesting population\u2010specific diagnostic characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13664","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T13:44:31Z","timestamp":1705067071000},"page":"2072-2079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Plasma biomarkers of Alzheimer's disease and related dementias in American Indians: The Strong Heart Study"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-7817","authenticated-orcid":false,"given":"Astrid M.","family":"Suchy\u2010Dicey","sequence":"first","affiliation":[{"name":"Washington State University Elson S Floyd College of Medicine  Spokane Washington USA"},{"name":"Huntington Medical Research Institutes  Pasadena California USA"},{"name":"Washington State University Institute for Research and Education to Address Community Health  Seattle Washington USA"},{"name":"University of Washington Alzheimer's Disease Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"W. 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