{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:59:22Z","timestamp":1783684762608,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG066506"],"award-info":[{"award-number":["P30AG066506"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32NS082168"],"award-info":[{"award-number":["T32NS082168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Magnetic resonance imaging (MRI) biomarkers are needed for indexing early biological stages of Alzheimer's disease (AD), such as plasma amyloid\u2010\u03b2 (A\u03b242\/40) positivity in A\u03b2 positron emission tomography (PET) negative individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Diffusion free\u2010water (FW) MRI was acquired in individuals with normal cognition (NC) and mild cognitive impairment (MCI) with A\u03b2 plasma\u2010\/PET\u2010 (NC\u00a0=\u00a022, MCI\u00a0=\u00a060), plasma+\/PET\u2010 (NC\u00a0=\u00a05, MCI\u00a0=\u00a020), and plasma+\/PET+ (AD dementia\u00a0=\u00a021) biomarker status. Gray and white matter FW and fractional anisotropy (FAt) were compared cross\u2010sectionally and the relationships between imaging, plasma and PET biomarkers were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Plasma+\/PET\u2010 demonstrated increased FW (24 regions) and decreased FAt (66 regions) compared to plasma\u2010\/PET\u2010. FW (16 regions) and FAt (51 regions) were increased in plasma+\/PET+ compared to plasma+\/PET\u2010. Composite brain FW correlated with plasma A\u03b242\/40 and p\u2010tau181.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>FW imaging changes distinguish plasma A\u03b242\/40 positive and negative groups, independent of group differences in cognitive status, A\u03b2 PET status, and other plasma biomarkers (i.e., t\u2010tau, p\u2010tau181, glial fibrillary acidic protein, neurofilament light).<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Plasma A\u03b242\/40 positivity is associated with brain microstructure decline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma+\/PET\u2010 demonstrated increased FW in 24 total GM and WM regions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma+\/PET\u2010 demonstrated decreased FAt in 66 total GM and WM regions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Whole\u2010brain FW correlated with plasma A\u03b242\/40 and p\u2010tau181 measures.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma+\/PET\u2010 demonstrated decreased cortical volume and thickness.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13693","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T07:04:43Z","timestamp":1709622283000},"page":"2830-2842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Diffusion MRI relates to plasma A\u03b242\/40 in PET negative participants without dementia"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-8765","authenticated-orcid":false,"given":"Jesse C.","family":"DeSimone","sequence":"first","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida USA"},{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010en","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida USA"},{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Loewenstein","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"Center for Cognitive Neuroscience and Aging University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan","family":"Duara","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center  Miami Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn E.","family":"Smith","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"Department of Clinical and Health Psychology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen N.","family":"McFarland","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"Department of Neurology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"Department of Neurology University of Florida  Gainesville Florida USA"},{"name":"Norman Fixel Institute for Neurological Diseases University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren M.","family":"Weber","sequence":"additional","affiliation":[{"name":"Quest Diagnostics Nichols Institute  San Juan Capistrano California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Barker","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center  Miami Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Coombes","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida USA"},{"name":"1Florida Alzheimer's Disease Research Center  Gainesville Florida USA"},{"name":"J. 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