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We used logistic regression to evaluate age, sex, education,\u00a0<jats:italic>APOE \u03b54<\/jats:italic>, neuritic plaques, and neurofibrillary tangles (NFTs) in CAA risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:italic>APOE \u03b54<\/jats:italic> increased CAA risk in all three groups, while younger age and higher NFT stages increased risk in AD and AD\u2010LBP. In AD\u2010LBP, male sex and lower education were additional risk factors. The odds of <jats:italic>APOE \u03b54<\/jats:italic> carrier homozygosity related to CAA was higher in LBP (25.69) and AD\u2010LBP (9.50) than AD (3.17).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>AD and LBPs modify risk factors for CAA and should be considered in reviewing the risk of CAA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Lewy body pathology modifies risk factors for cerebral amyloid angiopathy (CAA) when present along with Alzheimer's disease (AD) neuropathology.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In the context of anti\u2010amyloid monoclonal therapies and their associated risks for hemorrhage, the risk of underlying CAA in mixed dementia with Lewy body pathology needs to be considered.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13704","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T07:00:33Z","timestamp":1707894033000},"page":"2564-2574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lewy body pathology modifies risk factors for cerebral amyloid angiopathy when comorbid with Alzheimer's disease pathology"],"prefix":"10.1002","volume":"20","author":[{"given":"Jagan A.","family":"Pillai","sequence":"first","affiliation":[{"name":"Lou Ruvo Center for Brain Health Cleveland Clinic  Cleveland Ohio USA"},{"name":"Neurological Institute Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Neurology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bena","sequence":"additional","affiliation":[{"name":"Quantitative Health Sciences Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Tousi","sequence":"additional","affiliation":[{"name":"Lou Ruvo Center for Brain Health Cleveland Clinic  Cleveland Ohio USA"},{"name":"Neurological Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasia","family":"Rothenberg","sequence":"additional","affiliation":[{"name":"Lou Ruvo Center for Brain Health Cleveland Clinic  Cleveland Ohio USA"},{"name":"Neurological Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Dirk","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Leverenz","sequence":"additional","affiliation":[{"name":"Lou Ruvo Center for Brain Health Cleveland Clinic  Cleveland Ohio USA"},{"name":"Neurological Institute Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Neurology Cleveland Clinic  Cleveland Ohio 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