{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:59:35Z","timestamp":1759971575634,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG071849","R01AG054518","P50AG005133","P30AG066468"],"award-info":[{"award-number":["K01AG071849","R01AG054518","P50AG005133","P30AG066468"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We aimed to characterize the COVID\u201019 pandemic's relationship with enrollment in US Alzheimer's Disease Research Centers (ADRCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Using data on 10,105 participants from 30 ADRCs, we conducted interrupted time series analyses to assess the relationship of the pandemic with enrollment and calculate projected dates of enrollment recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Participants enrolled during the pandemic (vs pre\u2010pandemic) were more likely to have dementia and be referred by health professionals. The pandemic was associated with a 77% drop in enrollment, with projected trend recovery in March 2024 and 100% recovery in September 2024. COVID was associated with a 91% drop in Black\/African American participants, compared to 71% in White participants. Enrollment of both Hispanic and female participants was declining 1.4% and 0.3%\/month pre\u2010pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Funders and researchers should account for ongoing COVID\u201019 impact on ADRD research enrollment. Strategies to speed enrollment recovery are needed, especially for Black\/African American and Hispanic groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Tested COVID pandemic association with enrollment at Alzheimer's Disease Research Centers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>During versus pre\u2010pandemic enrollees differed on demographic and clinical variables.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Interrupted time series analyses: immediate 77% drop in enrollment related to COVID.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Recovery projections: trend recovery in March 2024, 100% recovery in September 2024.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Enrollment of African American and Hispanic participants should be prioritized.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13706","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T03:34:58Z","timestamp":1706758498000},"page":"2408-2419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["COVID\u201019 pandemic's relationship with enrollment at US Alzheimer's Disease Research Centers"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-1951","authenticated-orcid":false,"given":"C. 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Community Systems, School of Nursing University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer H.","family":"Lingler","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Health &amp; Community Systems, School of Nursing University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.34147"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.3857"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2021.10.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2022.114716"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.worlddev.2020.105296"},{"issue":"3","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1212\/CON.0000000000001088","article-title":"Health disparities in dementia","volume":"28","author":"Balls\u2010Berry JJE","year":"2022","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17345"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.12.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"Global status report on the public health response to dementia.World Health Organization;2021.","DOI":"10.1016\/S2468-2667(21)00215-2"},{"key":"e_1_2_8_11_1","unstructured":"US Department of Health and Human Services.The Belmont report: Ethical principles and guidelines for the protection of human subjects of research.Bethesday;1979."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.11.004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnab107"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2215609"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12160"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"AlsanM DurvasulaM GuptaH SchwartzsteinJ WilliamsH.Representation and Extrapolation: Evidence from Clinical Trials.National Bureau of Economic Research Inc;2022.","DOI":"10.3386\/w30575"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00123"},{"key":"e_1_2_8_18_1","unstructured":"National Institute on Aging.Expert panel offers transformative recommendations for NIH Alzheimer's research centers 2017.https:\/\/www.nia.nih.gov\/news\/expert\u2010panel\u2010offers\u2010transformative\u2010recommendations\u2010nih\u2010alzheimers\u2010research\u2010centers"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210027"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12076"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gny069"},{"key":"e_1_2_8_22_1","unstructured":"World Health Organization.WHO Director\u2010General's opening remarks at the media briefing on COVID\u201019 \u2010 11 March 2020.2020.https:\/\/www.who.int\/director-general\/speeches\/detail\/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000279"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"348","article-title":"Interrupted time series regression for the evaluation of public health interventions: a tutorial","volume":"46","author":"Bernal JL","year":"2017","journal-title":"Int J Epidemiol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/1913610"},{"volume-title":"The SAS System for Windows","year":"2013","author":"Inst. 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