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The double\u2010blind phase 3 DIAN\u2010TU\u2010001 trial tested clinical and cognitive declines with increasing doses of solanezumab or gantenerumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We used latent class (LC) analysis on data from the Dominantly Inherited Alzheimer Network Trials Unit 001 trial to test amyloid positron emission tomography (PET) reduction as a potential surrogate biomarker.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>LC analysis categorized participants into three classes: amyloid no change, amyloid reduction, and amyloid growth, based on longitudinal amyloid Pittsburgh compound B PET standardized uptake value ratio data. The amyloid\u2010no\u2010change class was at an earlier disease stage for amyloid amounts and dementia. Despite similar baseline characteristics, the amyloid\u2010reduction class exhibited reductions in the annual decline rates compared to the amyloid\u2010growth class across multiple biomarker, clinical, and cognitive outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>LC analysis indicates that amyloid reduction is associated with improved clinical outcomes and supports its use as a surrogate biomarker in clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We used latent class (LC) analysis to test amyloid reduction as a surrogate biomarker.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Despite similar baseline characteristics, the amyloid\u2010reduction class exhibited remarkably better outcomes compared to the amyloid\u2010growth class across multiple measures.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>LC analysis proves valuable in testing amyloid reduction as a surrogate biomarker in clinical trials lacking significant treatment effects.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13735","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T01:13:30Z","timestamp":1708737210000},"page":"2698-2706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Guoqiao","family":"Wang","sequence":"first","affiliation":[{"name":"Washington University, School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Washington University, School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Xiong","sequence":"additional","affiliation":[{"name":"Washington University, School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L. 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