{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:40:29Z","timestamp":1788514829291,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Little is known regarding quality of life (QoL) in dementia with Lewy bodies (DLB), particularly in advanced stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Dyads of individuals with moderate\u2013advanced DLB and their primary caregivers were recruited from specialty clinics, advocacy organizations, and research registries. The study collected demographics, disease\u2010related measures, and measures of patient\/caregiver experiences.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The Quality of Life in Alzheimer's Disease (QoL\u2010AD) was completed by the person with DLB and the caregiver (proxy) in 61 dyads; 85 dyads had only a proxy\u2010completed QoL\u2010AD. Patient\u2010 and proxy\u2010reported scores were moderately correlated (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.57, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Worse patient\u2010reported QoL correlated with daytime sleepiness, autonomic symptom burden, and behavioral symptoms. Proxy ratings correlated with dementia severity, daytime sleepiness, behavioral symptoms, dependence in activities of daily living, and caregiver experience measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Patient\u2010 and proxy\u2010reported quality of life (QoL) should be assessed separately in advanced DLB. Some symptoms associated with QoL have available therapeutic options. Research is needed regarding strategies to optimally improve QoL in DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Patient and proxy quality of life (QoL) ratings had moderate correlation in advanced dementia with Lewy bodies.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Daytime sleepiness affected patient\u2010 and proxy\u2010reported QoL.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Behavioral symptoms affected patient\u2010 and proxy\u2010reported QoL.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Autonomic symptom burden affected patient\u2010reported QoL.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Dementia severity, dependence, and caregiver experiences affected proxy ratings.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13745","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T01:03:20Z","timestamp":1708736600000},"page":"2719-2730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Patient\u2010 and proxy\u2010reported quality of life in advanced dementia with Lewy bodies"],"prefix":"10.1002","volume":"20","author":[{"given":"Melissa J.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Department of Neurology University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"LaBarre","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Sovich","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Maixner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry L.","family":"Paulson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lunde","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Galvin","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Brain Health Department of Neurology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Lewy Body Dementia Association  Lilburn Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318065c4a9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1422"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.78.1_MeetingAbstracts.P07.180"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190041"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00792-w"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5839"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.86.16_supplement.P6.234"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239279"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047554"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.03.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3916"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.05.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200310000-00002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.2.233"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.2.181"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.3.252"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.12.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12334"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.11.M546"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.02.014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909118800281"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2008.11.005"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.12.2.277"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/41.5.652"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/07481180590916335"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa5503&4_17"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/NUR.0000000000000148"},{"key":"e_1_2_7_32_1","first-page":"165","article-title":"Development and psychometric evaluation of the Resilience Scale","volume":"1","author":"Wagnild GM","year":"1993","journal-title":"J Nurs Meas"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/57.1.P74"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gny004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm0401_6"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e31818b504c"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.11.004"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000050"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2550"},{"key":"e_1_2_7_44_1","first-page":"1611","article-title":"Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: a meta\u2010analysis","volume":"17","author":"Meng YH","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30153-X"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471507"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211002614"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.13745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:54:36Z","timestamp":1759935276000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/alz.13745"],"URL":"https:\/\/doi.org\/10.1002\/alz.13745","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"2023-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}