{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:26:45Z","timestamp":1785292005402,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG051346"],"award-info":[{"award-number":["R01AG051346"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["5K23AG080117"],"award-info":[{"award-number":["5K23AG080117"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>This study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early\u2010stage Alzheimer's disease (AD) clinical trials. Their psychometric properties and associations with AD risk markers were compared to those of well\u2010established measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>For 291 older adults with healthy cognition or early mild cognitive impairment, Exploratory factor analyses were used to identify the factor structure of the NPE. Factor and total scores were examined for their psychometric properties and associations with AD risk biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Composite scores from the novel cognitive and functional measures demonstrated better psychometric properties (distribution and test\u2010retest reliability) and stronger associations with AD\u2010related demographic, genetic, and brain risk markers than well\u2010established measures,<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>These novel measures have potential for use as primary cognitive and functional outcomes in early\u2010stage AD clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Well\u2010established cognitive tests may not accurately detect subtle cognitive changes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>No Practice Effect (NPE) and Computerized Functional Skills Assessment and Training are novel measures designed to have improved psychometric properties.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>NPE had Executive Function, Cognitive Control\/Speed, and Episodic Memory domains.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Novel measures had better psychometric properties compared to established measures.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Significant associations with Alzheimer's disease biomarkers were found with novel measures.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13757","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T07:14:06Z","timestamp":1720077246000},"page":"5089-5101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-8224","authenticated-orcid":false,"given":"Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University Irving Medical Center  New York New York USA"},{"name":"Division of Geriatric Psychiatry New York State Psychiatric Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonjoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Geriatric Psychiatry New York State Psychiatric Institute  New York New York USA"},{"name":"Department of Biostatistics Mailman School of Public Health Columbia University  New York New York USA"},{"name":"Division of Mental Health Data Science New York State Psychiatric Institute  New York New York 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