{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:58:04Z","timestamp":1791140284556,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>To support clinical trial designs focused on early interventions, our study determined reliable early amyloid\u2010\u03b2 (A\u03b2) accumulation based on Centiloids (CL) in pre\u2010dementia populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease\u2013Prognostic and Natural History Study (AMYPAD\u2010PNHS) and Insight46 who underwent [\n                      <jats:sup>18<\/jats:sup>\n                      F]flutemetamol, [\n                      <jats:sup>18<\/jats:sup>\n                      F]florbetaben or [\n                      <jats:sup>18<\/jats:sup>\n                      F]florbetapir amyloid\u2010PET were included. A normative strategy was used to define reliable accumulation by estimating the 95\n                      <jats:sup>th<\/jats:sup>\n                      percentile of longitudinal measurements in sub\u2010populations (\n                      <jats:italic>N<\/jats:italic>\n                      <jats:sub>PNHS<\/jats:sub>\n                      \u00a0=\u00a0101\/750,\n                      <jats:italic>N<\/jats:italic>\n                      <jats:sub>Insight46<\/jats:sub>\n                      \u00a0=\u00a035\/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision\u2010recall analyses. Accumulation rates were examined using linear mixed\u2010effect models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Reliable accumulation in the PNHS was estimated to occur at\u00a0&gt;3.0 CL\/year. Baseline CL of 16 [12,19] best predicted future A\u03b2\u2010accumulators. Rates of amyloid accumulation were tracer\u2010independent, lower for APOE \u03b54 non\u2010carriers, and for subjects with higher levels of education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our results support a 12\u201320 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13761","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T16:59:48Z","timestamp":1712249988000},"page":"3429-3441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-7530","authenticated-orcid":false,"given":"Ariane","family":"Bollack","sequence":"first","affiliation":[{"name":"Centre for Medical Image Computing (CMIC) Department of Medical Physics and Bioengineering University College London  London London 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