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We aimed to identify WMH locations associated with vascular risk or cerebral amyloid\u2010\u03b2\n 1\u201042<\/jats:sub>\n (A\u03b242)\u2010positive status.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n Individual patient data (\n n<\/jats:italic>\n \u00a0=\u00a03,132; mean age 71.5\u00a0\u00b1\u00a09 years; 49.3% female) from 11 memory clinic cohorts were harmonized. WMH volumes in 28 regions were related to a vascular risk compound score (VRCS) and A\u00df42 status (based on cerebrospinal fluid or amyloid positron emission tomography), correcting for age, sex, study site, and total WMH volume.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n VRCS was associated with WMH in anterior\/superior corona radiata (B = 0.034\/0.038,\n p<\/jats:italic>\n \u00a0<\u00a00.001), external capsule (B = 0.052,\n p<\/jats:italic>\n \u00a0<\u00a00.001), and middle cerebellar peduncle (B = 0.067,\n p<\/jats:italic>\n \u00a0<\u00a00.001), and A\u00df42\u2010positive status with WMH in posterior thalamic radiation (B = 0.097,\n p<\/jats:italic>\n \u00a0<\u00a00.001) and splenium (B = 0.103,\n p<\/jats:italic>\n \u00a0<\u00a00.001).\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Vascular risk factors and A\u00df42 pathology have distinct signature WMH patterns. This regional vulnerability may incite future studies into how arteriolosclerosis and A\u00df42 pathology affect the brain's white matter.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH).<\/jats:p>\n <\/jats:list-item>\n \n We related WMH locations to vascular risk and cerebral A\u03b242 status in 11 memory clinic cohorts.<\/jats:p>\n <\/jats:list-item>\n \n A\u03b242 positive status was associated with posterior WMH in splenium and posterior thalamic radiation.<\/jats:p>\n <\/jats:list-item>\n \n Vascular risk was associated with anterior and infratentorial WMH.<\/jats:p>\n <\/jats:list-item>\n \n Amyloid pathology and vascular risk have distinct signature WMH patterns.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.13765","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T08:00:30Z","timestamp":1710316830000},"page":"2980-2989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-2148","authenticated-orcid":false,"given":"J. Matthijs","family":"Biesbroek","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery UMC Utrecht Brain Center Utrecht The Netherlands"},{"name":"Department of Neurology Diakonessenhuis Hospital Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirthe","family":"Coenen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery UMC Utrecht Brain Center Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan M.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.","family":"Maillard","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine Amsterdam UMC Vrije Universiteit Amsterdam The Netherlands"},{"name":"Queen Square Institute of Neurology and Centre for Medical Image Computing University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Barnes","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology UCL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Benke","sequence":"additional","affiliation":[{"name":"Clinic of Neurology Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P. L. H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Memory, Aging and Cognition Center National University Health System Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dal\u2010Bianco","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Dewenter","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD) LMU University Hospital LMU Munich M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Duering","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD) LMU University Hospital LMU Munich M\u00fcnchen Germany"},{"name":"Medical Image Analysis Center (MIAC) and Department of Biomedical Engineering University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Enzinger","sequence":"additional","affiliation":[{"name":"Division of General Neurology Department of Neurology Medical University Graz Graz Austria"},{"name":"Division of Neuroradiology Interventional and Vascular Radiology Department of Radiology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ewers","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD) LMU University Hospital LMU Munich M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieza G.","family":"Exalto","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery UMC Utrecht Brain Center Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Franzmeier","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD) LMU University Hospital LMU Munich M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Hilal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Memory, Aging and Cognition Center National University Health System Singapore Singapore"},{"name":"Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Hofer","sequence":"additional","affiliation":[{"name":"Division of Neurogeriatrics Department of Neurology Medical University of Graz Graz Austria"},{"name":"Institute for Medical Informatics Statistics and Documentation Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiberdina L.","family":"Koek","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea B.","family":"Maier","sequence":"additional","affiliation":[{"name":"Memory, Aging and Cognition Center National University Health System Singapore Singapore"},{"name":"Department of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl R.","family":"McCreary","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurosciences and Radiology and Hotchkiss Brain Institute University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne M.","family":"Papma","sequence":"additional","affiliation":[{"name":"Alzheimer Center Erasmus MC Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Internal Medicine Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross W.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology UCL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A. 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