{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:47:42Z","timestamp":1792550862561,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n We conducted a rapid systematic review of minimal clinically important differences (MCIDs) for Alzheimer's disease (AD) trial endpoints.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Two reviewers searched EMBASE, MEDLINE, and PubMed from inception to June 4, 2023.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Ten articles were retrieved. For mild cognitive impairment (MCI), a change of +2 to +3 points on the Alzheimer's Disease Assessment Scale\u2013Cognitive Subscale (ADAS\u2010Cog), +1 points on the Clinical Dementia Rating scale sum of boxes (CDR\u2010SB), \u22125 points on the integrated Alzheimer's Disease Rating Scale (iADRS), or \u22121 to \u22122 points on the Mini\u2010Mental State Examination (MMSE) was considered meaningful. For patients with mild AD, a change of +3 on the ADAS\u2010Cog, +2 points on CDR\u2010SB, \u22129 points on the iADRS, or \u22122 points on the MMSE was considered meaningful. For patients with moderate to severe AD, a change of +2 points on the CDR\u2010SB or a change of \u22121.4 to \u22123 points on the MMSE was considered meaningful.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n This review identified previously published MCIDs for AD trial endpoints. Input from patients and caregivers will be needed to derive more meaningful endpoints and thresholds.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n This systematic rapid review identified thresholds for minimal clinically important differences (MCIDs) for recently used Alzheimer's disease (AD) trial endpoints: Alzheimer's Disease Assessment Scale\u2013Cognitive Subscale (ADAS\u2010Cog), Clinical Dementia Rating scale sum of boxes (CDR\u2010SB), integrated Alzheimer's Disease Rating Scale (iADRS), Mini\u2010Mental State Examination (MMSE).<\/jats:p>\n <\/jats:list-item>\n \n MCIDs were higher for more severe stages of AD.<\/jats:p>\n <\/jats:list-item>\n \n Average treatment effects in recent trials of anti\u2010amyloid disease modifying monoclonal antibodies are lower than previously published MCIDs.<\/jats:p>\n <\/jats:list-item>\n \n In future trials of disease modifying treatments for AD, the proportion of participants in each treatment group that experienced a clinically meaningful decline could be reported.<\/jats:p>\n <\/jats:list-item>\n \n More work is needed to incorporate the values and preferences of patients and care partners in deriving MCIDs.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.13770","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T20:03:25Z","timestamp":1712001805000},"page":"3352-3363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Minimal clinically important difference in Alzheimer's disease: Rapid review"],"prefix":"10.1002","volume":"20","author":[{"given":"Ryan T.","family":"Muir","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences and Department of Community Health Sciences Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary Calgary Alberta 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