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This study examined mean ages of AD diagnosis and associations with co\u2010occurring conditions among adults with DS from five European countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data from 1335 people with DS from the Horizon 21 European DS Consortium were used for the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Mean ages of AD diagnosis ranged between 51.4 (SD 7.0) years (United Kingdom) and 55.6 (SD 6.8) years (France). Sleep\u2010related and mental health problems were associated with earlier age of AD diagnosis. The higher number of co\u2010occurring conditions the more likely the person with DS is diagnosed with AD at an earlier age.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Mean age of AD diagnosis in DS was relatively consistent across countries. However, co\u2010occurring conditions varied and impacted on age of diagnosis, suggesting that improvements can be made in diagnosing and managing these conditions to delay onset of AD in DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Mean age of AD diagnosis was relatively consistent between countries<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sleep problems and mental health problems were associated with earlier age of AD diagnosis<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>APOE \u03b54 carriers were diagnosed with AD at an earlier age compared to non\u2010carriers<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Number of co\u2010occurring conditions was associated with earlier age of AD diagnosis<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>No differences between level of intellectual disability and mean age of AD diagnosis<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13779","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T09:49:42Z","timestamp":1710928182000},"page":"3270-3280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-4137","authenticated-orcid":false,"given":"Frode Kibsgaard","family":"Larsen","sequence":"first","affiliation":[{"name":"The Norwegian National Centre for Ageing and Health Vestfold Hospital Trust  T\u00f8nsberg Norway"},{"name":"Institute of Clinical Medicine Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-2145","authenticated-orcid":false,"given":"R. 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