{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:34:55Z","timestamp":1790699695704,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["13129"],"award-info":[{"award-number":["13129"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["159910"],"award-info":[{"award-number":["159910"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cerebral small vessel disease (SVD) and amyloid beta (A\u03b2) pathology frequently co\u2010exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In a unique cohort of mixed Alzheimer's disease and moderate\u2013severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and A\u03b2, as assessed by\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Frontal WMH, occipital WMH, and A\u03b2 were independently associated with smaller hippocampal volume. Frontal WMH had a spatially distinct impact on hippocampal shape relative to A\u03b2. In contrast, hippocampal shape alterations associated with occipital WMH spatially overlapped with A\u03b2\u2010vulnerable subregions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Hippocampal degeneration is differentially sensitive to SVD and A\u03b2 pathology. The pattern of hippocampal atrophy could serve as a disease\u2010specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13791","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T17:53:28Z","timestamp":1712253208000},"page":"3687-3695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-8319","authenticated-orcid":false,"given":"Kristiana","family":"Xhima","sequence":"first","affiliation":[{"name":"Dr. Sandra E. Black Centre for Brain Resilience and Recovery LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Ottoy","sequence":"additional","affiliation":[{"name":"Dr. Sandra E. Black Centre for Brain Resilience and Recovery LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Gibson","sequence":"additional","affiliation":[{"name":"Dr. Sandra E. Black Centre for Brain Resilience and Recovery LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Zukotynski","sequence":"additional","affiliation":[{"name":"Dr. Sandra E. Black Centre for Brain Resilience and Recovery LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto  Toronto Ontario Canada"},{"name":"Departments of Medicine and Radiology McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medical Imaging Schulich School of Medicine and Dentistry, Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Scott","sequence":"additional","affiliation":[{"name":"Dr. Sandra E. Black Centre for Brain Resilience and Recovery LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginelle J.","family":"Feliciano","sequence":"additional","affiliation":[{"name":"Dr. Sandra E. Black Centre for Brain Resilience and Recovery LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Adamo","sequence":"additional","affiliation":[{"name":"Dr. Sandra E. 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