{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:22:08Z","timestamp":1782364928673,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG021055"],"award-info":[{"award-number":["R01AG021055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA32197"],"award-info":[{"award-number":["R01CA32197"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AG068353"],"award-info":[{"award-number":["K01AG068353"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest\u2010old (age 90+) participants of The 90+ Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Participants self\u2010reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as\u00a0&lt;\u00a07, 7 to 8\u00a0=\u00a0reference,\u00a0&gt;\u00a08\u00a0hours and dichotomized neuropathologic changes as present\/absent. We estimated odds ratio (OR) and 95% confidence intervals (CI) using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In 264 participants, mean age at sleep self\u2010report was 69 years, mean age at autopsy was 98 years, and mean interval between sleep self\u2010report and autopsy was 29 years (range: 19\u201340). Those reporting\u00a0&gt;\u00a08\u00a0hours of sleep had lower likelihood of limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy neuropathologic change (LATE\u2010NC) inclusions (OR\u00a0=\u00a00.18; CI\u00a0=\u00a00.04\u20130.82) and amyloid beta deposits (OR\u00a0=\u00a00.34; 95% CI\u00a0=\u00a00.12\u20130.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Long self\u2010reported sleep is associated with lower odds of neurodegenerative neuropathologic changes 19 to 40 years later in the oldest\u2010old, suggesting a potential role of sleep in accumulation of dementia\u2010related neuropathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Association of self\u2010reported sleep with non\u2010Alzheimer's disease neuropathologic changes has not been explored.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Whether sleep duration is related to dementia neuropathologic changes decades later is unclear.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Long self\u2010reported sleep is associated with lower odds of Alzheimer's disease neuropathologic change 19 to 40 years later in the oldest\u2010old.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Long self\u2010reported sleep is associated with lower odds of limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy neuropathologic change 19 to 40 years later in the oldest\u2010old.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.13798","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T07:00:48Z","timestamp":1712818848000},"page":"3495-3503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study"],"prefix":"10.1002","volume":"20","author":[{"given":"Zarui A.","family":"Melikyan","sequence":"first","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia H.","family":"Kawas","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"},{"name":"Department of Neurology University of California  Orange California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annlia","family":"Paganini\u2010Hill","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luohua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Bukhari","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Montine","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce A.","family":"Mander","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"},{"name":"Department of Psychiatry and Human Behavior University of California  Orange California USA"},{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Corrada","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"},{"name":"Department of Neurology University of California  Orange California USA"},{"name":"Department of Epidemiology and Biostatistics University of California  Irvine California 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