{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:13:55Z","timestamp":1793412835988,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Lewy body disease (LBD) is a common primary or co\u2010pathology in neurodegenerative syndromes. An alpha\u2010synuclein seed amplification assay (\u03b1Syn\u2010SAA) is clinically available, but clinical performance, especially lower sensitivity in amygdala\u2010predominant cases, is not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Antemortem CSF from neuropathology\u2010confirmed LBD cases was tested with \u03b1Syn\u2010SAA (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a056). Diagnostic performance and clinicopathological correlations were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Similar to prior reports, sensitivity was 100% for diffuse and transitional LBD (9\/9), and overall specificity was 96.3% (26\/27). Sensitivity was lower in amygdala\u2010predominant (6\/14, 42.8%) and brainstem\u2010predominant LBD (1\/6, 16.7%), but early spread outside these regions (without meeting criteria for higher stage) was more common in \u03b1Syn\u2010SAA\u2010positive cases (6\/7, 85.7%) than negative (2\/13, 15.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>In this behavioral neurology cohort, \u03b1Syn\u2010SAA had excellent diagnostic performance for cortical LBD. In amygdala\u2010 and brainstem\u2010predominant cases, sensitivity was lower, but positivity was associated with anatomical spread, suggesting \u03b1Syn\u2010SAA detects early LBD progression in these cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>A cerebrospinal fluid alpha\u2010synuclein assay detects cortical LBD with high sensitivity\/specificity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Positivity in prodromal stages of LBD was associated with early cortical spread.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The assay provides precision diagnosis of LBD that could support clinical trials.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The assay can also identify LBD co\u2010pathology, which may impact treatment responses.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.13799","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:29:52Z","timestamp":1711585792000},"page":"3334-3341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Clinicopathological correlation of cerebrospinal fluid alpha\u2010synuclein seed amplification assay in a behavioral neurology autopsy cohort"],"prefix":"10.1002","volume":"20","author":[{"given":"Niyatee","family":"Samudra","sequence":"first","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Luke","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lenio","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argentina","family":"Lario Lago","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Ljubenkov","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Seeley","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Spina","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Staffaroni","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Tablante","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fattin","family":"Wekselman","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lamoureux","sequence":"additional","affiliation":[{"name":"Amprion Inc.  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Concha\u2010Marambio","sequence":"additional","affiliation":[{"name":"Amprion Inc.  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea T.","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"},{"name":"Department of Pathology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawren","family":"VandeVrede","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.2000.tb00269.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010009\u20105324\u2010y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010023\u201011810\u20102"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002449\u20107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010023\u201002631\u20108"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010022\u201000787\u20103"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00109\u20106"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26453"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010022\u201001388\u20107"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30449\u2010X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29329"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx254"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.34.7.939"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0fd1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u20102006\u20109s347"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.2007.00117.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010011\u20100910\u20103"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010008\u20100460\u20105"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(02)00065\u20109"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab099"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010023\u201002663\u20100"},{"key":"e_1_2_8_29_1","first-page":"17","article-title":"A precision medicine approach to Dementia Care: syndrome, Etiology, and Copathology","volume":"2023","author":"Fischer DL","year":"2023","journal-title":"Pract Neurol (Fort Wash Pa)"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.19052"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010020\u201002255\u20102"}],"container-title":["Alzheimer's &amp; 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